Is Phloroglucinol safe in cosmetics?
Phloroglucinol has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Phloroglucinol
Also known as: 4-06-00-07361, BRN 1341907, EINECS 203-611-2, 5-Hydroxyresorcinol, UNII-DHD7FFG6YS (+14 more)
INCI: PHLOROGLUCINOL
Phloroglucinol (CAS 108-73-6) is a cosmetic cosmetic ingredient functioning as Hair Dyeing Coupler, Antioxidant, Anti-Melanogenic. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-73-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Phloroglucinol is classified GHS CMR hazard (H315, H317, H319, H335, H341, H361, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing Coupler, Antioxidant, Anti-Melanogenic
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
benzene-1,3,5-triol
InChIKey
QCDYQQDYXPDABM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Used in oxidative hair dyes under special exemption in FD&C Act, provided product label carries required caution statement and patch-test instructions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phloroglucinol.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1253
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1253
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 126.11
Log Kow: 0.16
Log Kp: -2.51
Log Jmax: -6.3741972174800745
Source: Roberts_Cheruvu_Mendeley_2022
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Phloroglucinol.
Regulatory Flags
endocrine_disruptor
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
4-06-00-07361
BRN 1341907
EINECS 203-611-2
5-Hydroxyresorcinol
UNII-DHD7FFG6YS
1,3, 5-Trihydroxybenzene
1,3,5-Benzenetriol (ACD/Name 4.0)
1,3,5-Trihydroxy-Benzene
1,3,5-Trihydroxycyclohexatriene
1,3,5-Triol
3,5-Dihydroxyphenol
5-Benzenetriol
5-Oxyresorcinol
5-Oxyresorcinolphloroglucin
Benzene, trihydroxy
Benzene-1,3,5-triol
Floroglucin
Phloroglucinol (1,3,5-benzenetriol)
Phloroglucinol (JAN)
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PHLOROGLUCINOL
ChEMBL ID
CHEMBL473159
Max Phase
3
Adverse Event Associations
266
Frequently Asked Questions
Is Phloroglucinol allowed in the EU?
Phloroglucinol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phloroglucinol do in cosmetics?
Phloroglucinol functions as: Hair Dyeing Coupler, Antioxidant, Anti-Melanogenic. It is classified as a cosmetic ingredient in our database. CAS number: 108-73-6.
Is Phloroglucinol used outside cosmetics?
Phloroglucinol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Phloroglucinol have different safety status in cosmetics vs industrial chemicals?
Phloroglucinol is classified GHS CMR hazard (H315, H317, H319, H335, H341, H361, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Phloroglucinol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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