Phloroglucinol
CAS 108-73-6
Phloroglucinol (CAS 108-73-6) is a Phase 3 pharmaceutical compound with 1 bioactivity target and 266 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | Ki | 8.815 nM | 2 | - |
| - | IC50 | 36470 nM | 1 | - |
| - | Potency | 23778.1 nM | 1 | - |
| Beta-secretase 1 Enzyme |
IC50 | 4.44 | - | Homo sapiens |
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Hepatocellular injury | 59 | 133.436 | 10019837 |
| Drug reaction with eosinophilia and systemic symptoms | 60 | 118.429 | 10073508 |
| Febrile bone marrow aplasia | 40 | 115.837 | 10053213 |
| Pancreatitis acute | 53 | 108.485 | 10033647 |
| Acute kidney injury | 132 | 102.295 | 10069339 |
| Cholestasis | 41 | 73.768 | 10008635 |
| Urethral valves | 13 | 73.327 | 10046479 |
| Hyperleukocytosis | 17 | 64.912 | 10078862 |
| Thrombocytopenia | 74 | 57.063 | 10043554 |
| Toxic skin eruption | 26 | 56.214 | 10057970 |
| Cell death | 17 | 55.289 | 10057248 |
| Eosinophilia | 32 | 53.765 | 10014950 |
| Drug ineffective | 8 | 49.679 | 10013709 |
| Abdominal pain | 82 | 47.586 | 10000081 |
| Puncture site haematoma | 8 | 46.495 | 10081957 |
| Foetal exposure during pregnancy | 40 | 44.382 | 10071404 |
| Hyponatraemia | 50 | 42.995 | 10021036 |
| Wrong product administered | 18 | 42.559 | 10081579 |
| Fatigue | 6 | 42.177 | 10016256 |
| Hypokalaemia | 45 | 41.889 | 10021015 |
| Neutropenia | 63 | 36.423 | 10029354 |
| Hepatic cytolysis | 20 | 34.466 | 10049199 |
| Acute generalised exanthematous pustulosis | 17 | 34.258 | 10048799 |
| Septum pellucidum agenesis | 6 | 34.015 | 10062267 |
| Rash maculo-papular | 26 | 33.991 | 10037868 |
| Coma | 34 | 33.613 | 10010071 |
| Poisoning deliberate | 17 | 33.374 | 10036000 |
| Gamma-glutamyltransferase increased | 26 | 33.112 | 10017693 |
| Encephalopathy | 27 | 31.292 | 10014625 |
| Hepatosplenic candidiasis | 7 | 31.051 | 10051590 |
| Bicytopenia | 11 | 30.95 | 10058956 |
| Femoral artery aneurysm | 6 | 30.541 | 10016427 |
| Cardiac septal defect | 8 | 30.428 | 10064021 |
| Lung disorder | 30 | 29.605 | 10025082 |
| Prerenal failure | 10 | 29.549 | 10072370 |
| Porphyria | 6 | 29.398 | 10036181 |
| Electrocardiogram QT prolonged | 30 | 29.053 | 10014387 |
| Arteriovenous fistula | 8 | 28.839 | 10003226 |
| Respiratory distress | 25 | 28.788 | 10038687 |
| Benign soft tissue neoplasm | 5 | 28.673 | 10061004 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Phloroglucinol used for in pharmaceutical contexts?
Phloroglucinol (CAS 108-73-6) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Phloroglucinol?
Phloroglucinol has 266 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Hepatocellular injury, Drug reaction with eosinophilia and systemic symptoms, Febrile bone marrow aplasia, Pancreatitis acute, Acute kidney injury. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Phloroglucinol also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Phloroglucinol with EU status "permitted".
What clinical phase is Phloroglucinol in?
Phloroglucinol is rendered with ChEMBL max phase 3.
What bioactivity targets are documented for Phloroglucinol?
Phloroglucinol has 4 bioactivity rows in this page query. Rendered target entries include Beta-secretase 1.