Excellent Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

D-Panthenol

Also known as: (+)-Panthenol, (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, Cozyme, D-Panthenol 75L, Ilopan (+15 more)

INCI: PANTHENOL

D-Panthenol (CAS 81-13-0) is a cosmetic cosmetic ingredient functioning as Hair and skin conditioning, humectant; provitamin B5. Reported NOAEL =200 mg/kg/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 81-13-0 →

Auto-generated CPSR Part A draft with source citations

CAS Number

81-13-0

View industrial chemical safety profile →

Function

Hair and skin conditioning, humectant; provitamin B5

Safety Rating

EXCELLENT

Chemistry & Identifiers

EC Number

201-327-3

ChEBI: CHEBI:27373 UNII: 1O6C93RI7Z Wikidata: Q47495755

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes FDA classifies panthenol as GRAS as a nutrient. Not subject to any FDA cosmetic restriction. Reported in 2017 FDA VCRP at concentrations up to 5.3% leave-on and 5% rinse-off. CIR Expert Panel 2022 issued safe conclusion for panthenol, pantothenic acid, and 5 derivatives at present cosmetic use concentrations.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for D-Panthenol.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for D-Panthenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	=200 mg/kg/d	oral	rat	oral toxicity	CIR_vision_codex
NOAEL	=200 mg/kg/d	oral	rat	oral toxicity	CIR_vision_codex
NOAEL	=200 mg/kg/d	oral	rat	oral toxicity	CIR_vision_codex
NOAEL	=200 mg/kg/d	oral	rat	oral toxicity	CIR_vision_codex
NOAEL	=1000 mg/kg/day	oral	rat	developmental toxicity	CIR_vision_codex
NOAEL	=1000 mg/kg/day	oral	rat	developmental toxicity	CIR_vision_codex
NOAEL	=1000 mg/kg/day	oral	rat	developmental toxicity	CIR_vision_codex
NOAEL	=1000 mg/kg/day	oral	rat	developmental toxicity	CIR_vision_codex

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir

Verdict: safe

NOAEL: 200 mg/kg/day (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir

Verdict: safe

NOAEL: 200 mg/kg/d (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir

Verdict: safe

NOAEL: 1 % (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir

Verdict: safe

NOAEL: 1 % (not specified)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

cir

Verdict: safe

NOAEL: 1000 mg/kg/d (oral)

gredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment. Keywords panthenol, pantothenic acid, cosmetics, safety Introduction This assessment reviews the safety of Panthenol, Pantothenic Acid and 5

EPA ToxValDB — Toxicity Values

2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint	Value	Species	Route	Duration	Source
LD50	>10000 mg/kg	Rat	oral	-	ECHA IUCLID
LD50	=15000 mg/kg	Mouse	oral	-	ChemIDplus

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000 - 10,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

No

Typical Use Concentrations

Reported concentration ranges per product category from SCCS/CIR/industry sources.

Product Category	Typical Range	Max Reported	Source
Shampoo	0.1–1	2	CIR/VCRP
Conditioner	0.5–2	3	CIR/VCRP
Face Cream	0.5–2	5	CIR/VCRP
Body Lotion	0.5–2	5	CIR/VCRP

Additional Ingredient Properties

7 property records from structured ingredient metadata.

baby_pediatric

{"cas_number": "81-13-0/16485-10-2", "ingredient_class": "moisturizer_baby", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Provitamin B5, barrier repair, anti-inflammatory, safe", "transepidermal_absorption_risk_pediatric": "very_low", "dose_per_kg_body_weight_concern": "Converts to…

comedogenicity_detail

{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,dry,sensitive,combination,normal,acne-prone,mature,rosacea", "acne_safe": "yes", "source": "Pro-vitamin B5"}

deodorant

{"cas_number": "81-13-0", "ingredient_class": "skin_conditioning_deo", "mechanism_of_action": "other", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "0", "odor_reduction_pct": "0", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "astringency_…

hair_care

{"hair_function": "moisturizing", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "balanced", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "ker…

regulatory

{"eu_status": "allowed", "us_status": "allowed"}

solubility_hlb

{"water_soluble": "yes", "oil_soluble": "partial", "soluble_in": "water, glycerin, propylene glycol, ethanol", "insoluble_in": "oils", "log_p": "-1.2", "melting_point_c": "66-69", "appearance": "clear viscous liquid", "source": "BASF"}

synergy

{"inci_name_2": "Hydrolyzed Keratin", "synergy_type": "efficacy-boost", "synergy_description": "Hair conditioning system with protein repair", "combined_benefit": "Enhanced color retention, improved hair strength, superior conditioning", "efficacy_multiplier": "1.7x", "mechanism_of_action": "Panthenol penetrates hair shaft providing moisture; keratin repairs protein structure", "optimal_ratio": "1…

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Emulsifier Flavouring and nutrient Softener and conditioner

Regulatory List Membership (3)

EU Regulated in Personal Care EPA Safer Chemical Ingredients List (SCIL) FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for D-Panthenol.

Regulatory Flags

rare-sensitizer rising-allergy-signal eczema-population-caution provitamin-b5 gras widely-used epa_safer_alternative fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to D-Panthenol by CAS number or substance name.

Studies

8

Lowest NOAEL

200

Highest NOAEL

1000

Units vary across source rows: mg/kg/d, mg/kg/day

CIR_vision_codex

Known Synonyms

(+)-Panthenol (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide Cozyme D-Panthenol 75L Ilopan Pantogel Pantol 4-04-00-01652 BRN 1724947 (R)-2,4-Dihydroxy-N-(3-hydroxy-propyl)-3,3-dimethylbutanamide 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, (R)- D(+)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide, D-(+)- 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, D-(+)- EINECS 201-327-3 Pantothenol Pantothenol, D- UNII-1O6C93RI7Z BAY 81-2996

Chemical Function

Softener and conditioner Emulsifier Flavouring and nutrient

Regulatory Lists

inert_ingredient; non_food_use; Pesticides SCIL (9/2019) food_additive; Substances Added to Food (formerly EAFUS) (2/2019) active_ingredient; Australia pharmaceutical active_ingredient; animal_products; Europe; pharmaceutical; residue Europe; supplements Europe; food_additive; supplements Canada; pharmaceutical Europe; Personal care Europe; Personal care - hair styling and care - shampoo-dandruff Europe; Personal care - hair styling and care - shampoo-dandruff

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound

DEXPANTHENOL

ChEMBL ID

CHEMBL1200979

Max Phase

4

Adverse Event Associations

1990

View full pharmaceutical profile →

Frequently Asked Questions

Is D-Panthenol safe in cosmetics?

D-Panthenol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is D-Panthenol allowed in the EU?

D-Panthenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does D-Panthenol do in cosmetics?

D-Panthenol functions as: Hair and skin conditioning, humectant; provitamin B5. It is classified as a cosmetic ingredient in our database. CAS number: 81-13-0.

What is the NOAEL for D-Panthenol?

The NOAEL (No Observed Adverse Effect Level) for D-Panthenol is =200 mg/kg/d based on a oral toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: CIR_vision_codex.

Is D-Panthenol used outside cosmetics?

D-Panthenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

Check D-Panthenol compliance across multiple jurisdictions:

Ingredient Decoder

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Substance Compliance

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Calculate Margin of Safety using SCCS methodology

Heavy Metal Limits

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