Is 1-Nitropropane safe in cosmetics?
1-Nitropropane has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
1-Nitropropane
Also known as: EINECS 203-544-9, UNII-39W305OW99, 3-nitropropane, nitropropane
INCI: NOT ASSIGNED A COSMETIC INCI (INDUSTRIAL SOLVENT; NOT A COSMETIC INGREDIENT)
1-Nitropropane (CAS 108-03-2) is a cosmetic cosmetic ingredient functioning as None in cosmetics - industrial solvent/chemical intermediate. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-03-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
1-Nitropropane is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H331, H332, H319, H335, H336).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
None in cosmetics - industrial solvent/chemical intermediate
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1-nitropropane
InChIKey
JSZOAYXJRCEYSX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not permitted as cosmetic ingredient; no cosmetic use history; OSHA PEL 25 ppm
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1-Nitropropane.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *
Hazard Statements
- H226 Flammable liquid and vapour
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
Specific Concentration Limits / M-factors
*
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Evidence for Carcinogenicity
A4; Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1050
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
... Human exposure to 1-NP concentrations exceeding 100 ppm reportedly causes eye irritation in humans. | The substance is irritating to the eyes and the respiratory tract. | A human eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for 1-Nitropropane.
Known Synonyms
EINECS 203-544-9
UNII-39W305OW99
3-nitropropane
nitropropane
Chemical Function
Solvent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1449933
Frequently Asked Questions
Is 1-Nitropropane allowed in the EU?
1-Nitropropane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 1-Nitropropane do in cosmetics?
1-Nitropropane functions as: None in cosmetics - industrial solvent/chemical intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 108-03-2.
Is 1-Nitropropane used outside cosmetics?
1-Nitropropane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 1-Nitropropane have different safety status in cosmetics vs industrial chemicals?
1-Nitropropane is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H331, H332, H319, H335, H336).
Compliance Tools
Check 1-Nitropropane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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