Is 1,3-Bis-(Isocyanatomethyl) Cyclohexane safe in cosmetics?
1,3-Bis-(Isocyanatomethyl) Cyclohexane has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Also known as: 1,3-Bis(methylisocyanate)cyclohexane, Cyclohexane, 1,3-bis(isocyanatomethyl)-, 1,3-Bis(methylisocyanate)cyclohexane [Diisocyanates]
INCI: 1,3-BIS-(ISOCYANATOMETHYL) CYCLOHEXANE
1,3-Bis-(Isocyanatomethyl) Cyclohexane (CAS 38661-72-2) is a cosmetic cosmetic ingredient functioning as Monomer / cross-linking agent used in polyurethane-based nail and film-forming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 38661-72-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
1,3-Bis-(Isocyanatomethyl) Cyclohexane is classified GHS Danger (H302, H312, H314, H315, H317, H318, H319, H330) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Monomer / cross-linking agent used in polyurethane-based nail and film-forming products
Safety Rating
POOR
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA cosmetic restriction; OSHA workplace exposure limits apply
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1,3-Bis-(Isocyanatomethyl) Cyclohexane.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for 1,3-Bis-(Isocyanatomethyl) Cyclohexane.
Known Synonyms
1,3-Bis(methylisocyanate)cyclohexane
Cyclohexane, 1,3-bis(isocyanatomethyl)-
1,3-Bis(methylisocyanate)cyclohexane [Diisocyanates]
Chemical Function
No specific technical function
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 1,3-Bis-(Isocyanatomethyl) Cyclohexane allowed in the EU?
1,3-Bis-(Isocyanatomethyl) Cyclohexane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,3-Bis-(Isocyanatomethyl) Cyclohexane do in cosmetics?
1,3-Bis-(Isocyanatomethyl) Cyclohexane functions as: Monomer / cross-linking agent used in polyurethane-based nail and film-forming products. It is classified as a cosmetic ingredient in our database. CAS number: 38661-72-2.
Is 1,3-Bis-(Isocyanatomethyl) Cyclohexane used outside cosmetics?
1,3-Bis-(Isocyanatomethyl) Cyclohexane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 1,3-Bis-(Isocyanatomethyl) Cyclohexane have different safety status in cosmetics vs industrial chemicals?
1,3-Bis-(Isocyanatomethyl) Cyclohexane is classified GHS Danger (H302, H312, H314, H315, H317, H318, H319, H330) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 1,3-Bis-(Isocyanatomethyl) Cyclohexane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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