Is Ethyl Butyrate safe in cosmetics?
Ethyl Butyrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Ethyl Butyrate
INCI: ETHYL BUTYRATE
Ethyl Butyrate (CAS 105-54-4) is a cosmetic cosmetic ingredient functioning as Perfuming, Masking. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 105-54-4 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming, Masking
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
ethyl butanoate
InChIKey
OBNCKNCVKJNDBV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS #2427 (21 CFR 182.60); no FDA cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Butyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Butyrate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3240 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Vapor: Irritating to eyes, nose and throat. Liquid: Irritating to skin and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
29
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTANOIC ACID ETHYL ESTER | 1996 | 0-15 mg/kg bw (1967) | No safety concern at current levels of intake when used as a flavouring agent. The 1967 ADI of 0-15 mg/kg bw was maintained at the forty-sixth meeting (1996). | TRS 868-JECFA 46/21 | See TRS 868-JECFA 46/64
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Plasticizer
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Butyrate.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Butyrate by CAS number or substance name.
Studies
6
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Chemical Function
Fragrance
Solvent
Flavouring and nutrient
Plasticizer
Regulatory Lists
detected; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
air; consumer_product; detected; emissions
air; detected; emissions; Personal care
air; Cleaning products and household care - air freshener; detected; emissions
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
air; detected; emissions; Europe; Vehicle - car interior
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL44800
Frequently Asked Questions
Is Ethyl Butyrate allowed in the EU?
Ethyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Butyrate do in cosmetics?
Ethyl Butyrate functions as: Perfuming, Masking. It is classified as a cosmetic ingredient in our database. CAS number: 105-54-4.
Is Ethyl Butyrate used outside cosmetics?
Ethyl Butyrate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Butyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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