Is 1,6-Hexamethylene Diisocyanate (HDI) safe in cosmetics?
1,6-Hexamethylene Diisocyanate (HDI) has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
1,6-Hexamethylene Diisocyanate (HDI)
Also known as: 1,6-Hexamethylene diisocyanate, 1,6-Diisocyanatohexamethylene, HMDI, NSC 11687, MODIFIED HEXAMETHYL DIISOCYANATE (+12 more)
INCI: HEXAMETHYLENE DIISOCYANATE
1,6-Hexamethylene Diisocyanate (HDI) (CAS 822-06-0) is a cosmetic cosmetic ingredient functioning as Monomer and crosslinker in polymer synthesis; not a direct cosmetic ingredient. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 822-06-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
1,6-Hexamethylene Diisocyanate (HDI) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319, H330, H331, H334, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Monomer and crosslinker in polymer synthesis; not a direct cosmetic ingredient
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not permitted as a standalone ingredient; monitored as residual impurity in HDI polymers
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1,6-Hexamethylene Diisocyanate (HDI).
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
SkullToxicCancerHealth haz
Hazard Statements
Fatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction
Short-term Exposure Effects
The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Inhalation may cause asthmatic reactions.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol or vapour and through the skin.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 1,6-Hexamethylene Diisocyanate (HDI) across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute ToxicityHealth Hazard
Hazard Class and Category
Acute Tox. 3 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1
Hazard Statements
- H331 Toxic if inhaled
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H317 May cause an allergic skin reaction
Specific Concentration Limits / M-factors
*; Resp. Sens. 1; H334: C ≥ 0.5%; Skin Sens. 1; H317: C ≥ 0.5%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Chemical reaction regulator
Hardener
Monomers
No specific technical function
Polymerization promoter
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for 1,6-Hexamethylene Diisocyanate (HDI).
Known Synonyms
1,6-Hexamethylene diisocyanate
1,6-Diisocyanatohexamethylene
HMDI
NSC 11687
MODIFIED HEXAMETHYL DIISOCYANATE
UN 2281
BRN 0956709
EINECS 212-485-8
Isocyanic acid, diester with 1,6-hexanediol
Hexamethylendiisokyanat
Metyleno-bis-fenyloizocyjanian
Szesciometylenodwuizocyjanian
UNII-0I70A3I1UF
1,6-Hexanediol diisocyanate
HDI
Hexamethylene-1,6-diisocyanate
Hexane 1,6-diisocyanate
Chemical Function
Monomers
Solvent
Chemical reaction regulator
Catalyst
Polymerization promoter
Regulatory Lists
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
Europe; Toys and children's products
CEDI
Indirect additives food contact (10/2018)
Cons electronics mech appliances and machinery; Europe; nondetect
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1896533
Frequently Asked Questions
Is 1,6-Hexamethylene Diisocyanate (HDI) allowed in the EU?
1,6-Hexamethylene Diisocyanate (HDI) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,6-Hexamethylene Diisocyanate (HDI) do in cosmetics?
1,6-Hexamethylene Diisocyanate (HDI) functions as: Monomer and crosslinker in polymer synthesis; not a direct cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 822-06-0.
Is 1,6-Hexamethylene Diisocyanate (HDI) classified as hazardous under GHS?
1,6-Hexamethylene Diisocyanate (HDI) carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Toxic in contact with skin Causes serious eye irritation Causes skin irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is 1,6-Hexamethylene Diisocyanate (HDI) used outside cosmetics?
1,6-Hexamethylene Diisocyanate (HDI) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 1,6-Hexamethylene Diisocyanate (HDI) have different safety status in cosmetics vs industrial chemicals?
1,6-Hexamethylene Diisocyanate (HDI) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319, H330, H331, H334, H335).
Compliance Tools
Check 1,6-Hexamethylene Diisocyanate (HDI) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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