Is HC Yellow No. 6 safe in cosmetics?
HC Yellow No. 6 has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
HC Yellow No. 6
INCI: HC YELLOW NO. 6
HC Yellow No. 6 (CAS 104333-00-8) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 104333-00-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Yellow No. 6 is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H412).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
3-[2-nitro-4-(trifluoromethyl)anilino]propane-1,2-diol
InChIKey
XDHQHBSDKYPJRG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not FDA-listed; coal-tar hair dye exemption may technically apply but no CIR review exists
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Yellow No. 6.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Aquatic Chronic 3
Hazard Statements
- H302 Harmful if swallowed
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1324
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1324
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Yellow No. 6.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is HC Yellow No. 6 allowed in the EU?
HC Yellow No. 6 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Yellow No. 6 do in cosmetics?
HC Yellow No. 6 functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 104333-00-8.
Is HC Yellow No. 6 used outside cosmetics?
HC Yellow No. 6 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Yellow No. 6 have different safety status in cosmetics vs industrial chemicals?
HC Yellow No. 6 is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H412).
Compliance Tools
Check HC Yellow No. 6 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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