What is the GHS hazard classification for HC Yellow 6?
HC Yellow 6 (CAS 104333-00-8) is classified under EU CLP Annex VI as Acute Tox. 4 *; Aquatic Chronic 3 with signal word Warning. Hazard statements: H302; H412. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
HC Yellow 6
CAS 104333-00-8
HC Yellow 6 (CAS 104333-00-8) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H412. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
HC Yellow 6 is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H412).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
HC Yellow 6
CAS Number
104333-00-8
DTXSID
DTXSID50879804
Molecular Formula
C10H11F3N2O4
InChI Key
XDHQHBSDKYPJRG-UHFFFAOYSA-N
Monoisotopic Mass
280.067091
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Aquatic Chronic 3 | H302; H412 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| C3I439FV6T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C3I439FV6T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C3I439FV6T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C3I439FV6T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-((2-nitro-4-(trifluoromethyl)phenyl)amino)propane-1,2-diol | 410-010-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What is the NOAEL for HC Yellow 6?
HC Yellow 6 has 4 NOAEL studies in the database. The lowest reported value is C3I439FV6T UNII. Source: openFDA substances.
What regulatory lists include HC Yellow 6?
HC Yellow 6 appears on 2 regulatory/inventory lists including banned; Europe; Personal care, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is HC Yellow 6 used in cosmetics?
Yes, HC Yellow 6 is also indexed as a cosmetic ingredient under the name HC Yellow No. 6. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for HC Yellow 6 come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does HC Yellow 6 have different safety status in cosmetics vs industrial chemicals?
HC Yellow 6 is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H412).
Is HC Yellow 6 used outside industrial chemicals?
HC Yellow 6 also appears in cosmetics databases.