Is 2,2'-Thiobis(4-Chlorophenol) safe in cosmetics?
2,2'-Thiobis(4-Chlorophenol) has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
2,2'-Thiobis(4-Chlorophenol)
Also known as: D 25-Antimykotikum, 4-06-00-05645, Bis(2-hydroxy-5-chlorophenyl) sulfide, BRN 2057140, Caswell No. 851 (+13 more)
INCI: FENTICHLOR
2,2'-Thiobis(4-Chlorophenol) (CAS 97-24-5) is a cosmetic cosmetic ingredient functioning as Antimicrobial / antifungal agent. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97-24-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,2'-Thiobis(4-Chlorophenol) is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H335, H413).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial / antifungal agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-chloro-2-(5-chloro-2-hydroxyphenyl)sulfanylphenol
InChIKey
ANUSOIHIIPAHJV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not permitted in OTC antiseptic products; not generally recognized as safe for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,2'-Thiobis(4-Chlorophenol).
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for 2,2'-Thiobis(4-Chlorophenol).
Regulatory Flags
potential-allergen
Known Synonyms
D 25-Antimykotikum
4-06-00-05645
Bis(2-hydroxy-5-chlorophenyl) sulfide
BRN 2057140
Caswell No. 851
2,2'-Dihydroxy-5,5'-dichlorodiphenyl sulfide
EINECS 202-568-7
EPA Pesticide Chemical Code 064209
Meflorin
NSC 4112
Ovitrol
NSC 55636
Fenticloro
Fenticlorum
UNII-D61659OVD0
2,2'-Dihydroxy-5,5'-dichlorophenyl sulfide
2,2'-Thiobis4-chlorophenol
5,5'-Dichloro-2,2'-dihydroxydiphenyl sulfide
Chemical Function
Biocide
Regulatory Lists
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
FENTICLOR
ChEMBL ID
CHEMBL473535
Max Phase
2
Adverse Event Associations
31
Frequently Asked Questions
Is 2,2'-Thiobis(4-Chlorophenol) allowed in the EU?
2,2'-Thiobis(4-Chlorophenol) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,2'-Thiobis(4-Chlorophenol) do in cosmetics?
2,2'-Thiobis(4-Chlorophenol) functions as: Antimicrobial / antifungal agent. It is classified as a cosmetic ingredient in our database. CAS number: 97-24-5.
Is 2,2'-Thiobis(4-Chlorophenol) used outside cosmetics?
2,2'-Thiobis(4-Chlorophenol) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,2'-Thiobis(4-Chlorophenol) have different safety status in cosmetics vs industrial chemicals?
2,2'-Thiobis(4-Chlorophenol) is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H335, H413).
Compliance Tools
Check 2,2'-Thiobis(4-Chlorophenol) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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