Is Basic Red 1 safe in cosmetics?
Basic Red 1 has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database.
Basic Red 1
Also known as: Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, chloride (1:1), C.I. Basic Red 1, monohydrochloride, Basic Rhodamine Yellow, Basic Rhodaminic Yellow, Benzoic acid, 2-(6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl)-, ethyl ester, monohydrochloride (+15 more)
INCI: BASIC RED 1
Basic Red 1 (CAS 989-38-8) is a cosmetic cosmetic ingredient functioning as Hair dyeing. Reported NOAEL =19.5 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 989-38-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Basic Red 1 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H317, H318, H400, H410, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not approved as cosmetic color additive
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Basic Red 1.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Basic Red 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =19.5 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =24 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
16, Sup 7
Evaluation Year
1987
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute ToxicityCorrosiveEnvironmental Hazard
Hazard Class and Category
Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H301 Toxic if swallowed
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
oral: ATE = 280.0 mg/kg bw; M = 10; M = 1
Inserted via ATP: ATP21
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Basic Red 1.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Basic Red 1 by CAS number or substance name.
Studies
2
Lowest NOAEL
19.5 mg/kg bw/day
Highest NOAEL
24 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, chloride (1:1)
C.I. Basic Red 1, monohydrochloride
Basic Rhodamine Yellow
Basic Rhodaminic Yellow
Benzoic acid, 2-(6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl)-, ethyl ester, monohydrochloride
CI Basic Red 1
CI Basic Red 1, monohydrochloride
EINECS 213-584-9
Elcozine Rhodamine 6GDN
Mitsui Rhodamine
NCI-C56122
Rhodamine F4G
Rhodamine F5G
Rhodamine J
Rhodamine 6ZH
Rhodamine 7JH
Rhodamine 6 G extra
Rhodamine F5G chloride
Rhodamine 6G Extra
Rhodamine 6GDN Extra
Chemical Function
Dye
Regulatory Lists
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL5305690
Frequently Asked Questions
Is Basic Red 1 allowed in the EU?
Basic Red 1 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Basic Red 1 do in cosmetics?
Basic Red 1 functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 989-38-8.
What is the NOAEL for Basic Red 1?
The NOAEL (No Observed Adverse Effect Level) for Basic Red 1 is =19.5 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Basic Red 1 used outside cosmetics?
Basic Red 1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Basic Red 1 have different safety status in cosmetics vs industrial chemicals?
Basic Red 1 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H317, H318, H400, H410, H411).
Compliance Tools
Check Basic Red 1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Poor
Similar safety
Monomer / cross-linking agent used in...
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1,6-Hexamethylene Diisocyanate (HDI)
Poor
Similar safety
Monomer and crosslinker in polymer sy...
1,6-Hexanediamine
Poor
Similar safety
Industrial chemical (nylon monomer); ...
1-Nitropropane
Poor
Similar safety
None in cosmetics - industrial solven...
2,2'-Thiobis(4-Chlorophenol)
Poor
Similar safety
Antimicrobial / antifungal agent
EGCG (Epigallocatechin Gallate)
Good
Chemical family
UV Filter
Epigallocatechin Gallate
Excellent
Chemical family
Antioxidant; green tea catechin polyp...
BASIC BLUE 9
Moderate
Browse nearby
Hair Dyeing
Is Basic Red 1 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Basic Red 1 in your formulation.