Is Epigallocatechin Gallate safe in cosmetics?
Epigallocatechin Gallate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Epigallocatechin Gallate
Also known as: EGCG, (-)-Epigallocatechin-3-o-gallate, (-)-Epigallocatechol gallate, Tea catechin, Teavigo (+7 more)
INCI: EPIGALLOCATECHIN GALLATE
Epigallocatechin Gallate (CAS 989-51-5) is a cosmetic antioxidant functioning as Antioxidant; green tea catechin polyphenol; HAT/SET free radical scavenger;. Reported NOAEL =50 mg/kg bw/day in Dog (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 989-51-5 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant; green tea catechin polyphenol; HAT/SET free radical scavenger; metal chelator; anti-inflammatory; inhibits UV-induced immunosuppression
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions. Green tea extract generally regarded as safe at cosmetic use concentrations. CIR has addressed green tea-derived ingredients broadly.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Epigallocatechin Gallate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Epigallocatechin Gallate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Dog | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Epigallocatechin Gallate.
Regulatory Flags
antioxidant
polyphenol
green-tea
hat-set-mechanism
metal-chelator
hydrophilic
encapsulation-recommended
uv-immunoprotection
anti-pollution
unstable
delivery-challenge
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Epigallocatechin Gallate by CAS number or substance name.
Studies
1
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
50 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EGCG
(-)-Epigallocatechin-3-o-gallate
(-)-Epigallocatechol gallate
Tea catechin
Teavigo
NVP-XAA 723
L-Epigallocatechin gallate
Epigallocatechin-3-monogallate
UNII-BQM438CTEL
Epigallocatechin 3-gallate
[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
(-)-epigallocatechin 3-gallate
Chemical Function
Antioxidant
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EPIGALOCATECHIN GALLATE
ChEMBL ID
CHEMBL297453
Max Phase
3
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Epigallocatechin gallate
Food Category
preservative
Frequently Asked Questions
Is Epigallocatechin Gallate allowed in the EU?
Epigallocatechin Gallate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Epigallocatechin Gallate do in cosmetics?
Epigallocatechin Gallate functions as: Antioxidant; green tea catechin polyphenol; HAT/SET free radical scavenger; metal chelator; anti-inflammatory; inhibits UV-induced immunosuppression. It is classified as a Antioxidant in our database. CAS number: 989-51-5.
What is the NOAEL for Epigallocatechin Gallate?
The NOAEL (No Observed Adverse Effect Level) for Epigallocatechin Gallate is =50 mg/kg bw/day based on a subchronic study via oral route in Dog. Source: ToxValDB_ECHA_IUCLID.
Is Epigallocatechin Gallate used outside cosmetics?
Epigallocatechin Gallate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Epigallocatechin Gallate compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Basic Red 1
Poor
Chemical family
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EGCG (Epigallocatechin Gallate)
Good
Chemical family
UV Filter
EPOXY RESIN COATED ALUMINUM POWDER
Good
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