Also known as: Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, chloride (1:1), C.I. Basic Red 1, monohydrochloride, Basic Rhodamine Yellow, Basic Rhodaminic Yellow, Benzoic acid, 2-(6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl)-, ethyl ester, monohydrochloride (+15 more)
CAS 989-38-8
Rhodamine 6G (CAS 989-38-8) is a chemical substance with GHS signal word Danger; key hazard signal: H301; H318; H317; H400; H410. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, EPA TRI.
Rhodamine 6G is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H318, H317, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 16, Sup 7 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 | H301; H318; H317; H400; H410 | GHS06; GHS05; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6.46280698601278 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 11.97684311 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 0.153076124 | uM | ACC | - | - | NTP_ICE_endocrine |
| 1.81604039146967 | uM | ACC | - | - | NTP_ICE_endocrine |
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 037VRW83CF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 037VRW83CF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 037VRW83CF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 037VRW83CF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3.14e-7 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =10 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =10 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =12 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =12 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =125 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =125 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =210 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =210 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.158 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.528 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =5 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =5 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =19.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =24 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | ppm | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 250 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| 0.025 | % | Top dose | Dosed feed | Rat | NTP_ICE_cancer |
| 0.1 | % | Top dose | Dosed feed | Mouse | NTP_ICE_cancer |
| 0.2 | % | Top dose | Dosed feed | Mouse | NTP_ICE_cancer |
Showing 35 of 35 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethylxanthylium chloride | 213-584-9 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| C.I. Basic Red 1 | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Rhodamine 6G (CAS 989-38-8) is classified under EU CLP Annex VI as Acute Tox. 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H301; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
Rhodamine 6G has 35 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
Rhodamine 6G appears on 2 regulatory/inventory lists including Canada; pharmaceutical, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Rhodamine 6G is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Rhodamine 6G is also indexed as a cosmetic ingredient under the name Basic Red 1. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Rhodamine 6G is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H318, H317, H400, H410).
Rhodamine 6G also appears in cosmetics, pharmaceutical databases.