Is 4,4'-Diaminodiphenylamine safe in cosmetics?
4,4'-Diaminodiphenylamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
4,4'-Diaminodiphenylamine
Also known as: Aniline, 4,4'-iminodi-, Benzenamine, 4,4'-iminobis-, Bis(p-aminophenyl)amine, p,p'-Diaminodiphenylamine, Di(p-aminophenyl)amine (+6 more)
INCI: 4,4'-DIAMINODIPHENYLAMINE
4,4'-Diaminodiphenylamine (CAS 537-65-5) is a cosmetic cosmetic ingredient functioning as Hair Dye (oxidative). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 537-65-5 →
Auto-generated CPSR Part A draft with source citations
Function
Hair Dye (oxidative)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-N-(4-aminophenyl)benzene-1,4-diamine
InChIKey
QZHXKQKKEBXYRG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Technically permissible under coal tar hair dye exemption (FD&C Act §601(a)) with mandatory caution labeling and patch test instructions; not an approved color additive
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4,4'-Diaminodiphenylamine.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1309
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1309
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 4,4'-Diaminodiphenylamine.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Aniline, 4,4'-iminodi-
Benzenamine, 4,4'-iminobis-
Bis(p-aminophenyl)amine
p,p'-Diaminodiphenylamine
Di(p-aminophenyl)amine
Diazol Black C
EINECS 208-673-4
Indamine
NSC 33417
p-Phenylenediamine, N-(p-aminophenyl)-
UNII-R24HL8M2C7
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL274986
Frequently Asked Questions
Is 4,4'-Diaminodiphenylamine allowed in the EU?
4,4'-Diaminodiphenylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4,4'-Diaminodiphenylamine do in cosmetics?
4,4'-Diaminodiphenylamine functions as: Hair Dye (oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 537-65-5.
Is 4,4'-Diaminodiphenylamine used outside cosmetics?
4,4'-Diaminodiphenylamine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4,4'-Diaminodiphenylamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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