Is Pterostilbene safe in cosmetics?
Pterostilbene has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Pterostilbene
Also known as: 3,5-Dimethoxy-4'-hydroxy-trans-stilbene, 4-Stilbenol, 3',5'-dimethoxy-, (E)-, 4-((E)-2-(3,5-Dimethoxyphenyl)ethenyl)phenol, (E)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene, (E)-3',5'-dimethoxy-4-stilbenol (+6 more)
INCI: PTEROSTILBENE
Pterostilbene (CAS 537-42-8) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin Conditioning, Anti-aging (collagen protection,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 537-42-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Pterostilbene is classified GHS Danger (H318, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant, Skin Conditioning, Anti-aging (collagen protection, anti-inflammatory)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
InChIKey
VLEUZFDZJKSGMX-ONEGZZNKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; GRAS for food applications; no specific CIR review
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pterostilbene.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, brightening", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "…
anti_pollution
{"cas_number": "537-42-8", "ingredient_class": "Nrf2_activator", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_k…
antioxidant
{"cas_number": "537-42-8", "antioxidant_class": "polyphenol", "chemical_subclass": "methylated stilbene", "molecular_weight_daltons": "256.3", "orac_value_umol_te_per_g": "16500", "dpph_radical_scavenging_ic50_ug_per_ml": "10-18", "abts_trolox_equivalent": "1.2", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "yes", "hydroxyl_radical_scavenging": "high", "lipid_peroxidation_in…
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "320", "estimated_cost_per_kg_usd_high": "600", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "US/China", "bulk_discount_threshold_kg": "5", "seasonal_price_variation": "medium", "commodity_or_specialty": "specialty", "substitute_ingredients": "Resverat…
uv_stability
{"uv_stable": "partially", "uv_degradation_rate": "moderate", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "yes", "odor_change_uv": "no", "efficacy_loss_uv_pct": "30", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Pterostilbene.
Known Synonyms
3,5-Dimethoxy-4'-hydroxy-trans-stilbene
4-Stilbenol, 3',5'-dimethoxy-, (E)-
4-((E)-2-(3,5-Dimethoxyphenyl)ethenyl)phenol
(E)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene
(E)-3',5'-dimethoxy-4-stilbenol
(E)-4'-hydroxy-3,5-dimethoxystilbene
3',5'-dimethoxy-4-stilbenol
3',5'-dimethoxy-resveratrol
4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol
4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol
trans-pterostilbene
Chemical Function
Antioxidant
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PTEROSTILBENE
ChEMBL ID
CHEMBL83527
Max Phase
2
Frequently Asked Questions
Is Pterostilbene allowed in the EU?
Pterostilbene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pterostilbene do in cosmetics?
Pterostilbene functions as: Antioxidant, Skin Conditioning, Anti-aging (collagen protection, anti-inflammatory). It is classified as a cosmetic ingredient in our database. CAS number: 537-42-8.
Is Pterostilbene used outside cosmetics?
Pterostilbene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Pterostilbene have different safety status in cosmetics vs industrial chemicals?
Pterostilbene is classified GHS Danger (H318, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Pterostilbene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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