What is the NOAEL for 1,4-Benzenediamine, N-(4-aminophenyl)-?
1,4-Benzenediamine, N-(4-aminophenyl)- has 4 NOAEL studies in the database. The lowest reported value is R24HL8M2C7 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
1,4-Benzenediamine, N-(4-aminophenyl)-
Also known as: Aniline, 4,4'-iminodi-, Benzenamine, 4,4'-iminobis-, Bis(p-aminophenyl)amine, p,p'-Diaminodiphenylamine, Di(p-aminophenyl)amine (+7 more)
CAS 537-65-5
1,4-Benzenediamine, N-(4-aminophenyl)- (CAS 537-65-5) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for 4,4'-Diaminodiphenylamine →
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
1,4-Benzenediamine, N-(4-aminophenyl)-
CAS Number
537-65-5
DTXSID
DTXSID1060217
Molecular Formula
C12H13N3
InChI Key
QZHXKQKKEBXYRG-UHFFFAOYSA-N
Monoisotopic Mass
199.110947
Synonyms
Aniline, 4,4'-iminodi-Benzenamine, 4,4'-iminobis-Bis(p-aminophenyl)aminep,p'-DiaminodiphenylamineDi(p-aminophenyl)amineDiazol Black CEINECS 208-673-4IndamineNSC 33417p-Phenylenediamine, N-(p-aminophenyl)-UNII-R24HL8M2C74,4'-Diaminodiphenylamine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| R24HL8M2C7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R24HL8M2C7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R24HL8M2C7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R24HL8M2C7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL274986
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include 1,4-Benzenediamine, N-(4-aminophenyl)-?
1,4-Benzenediamine, N-(4-aminophenyl)- appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is 1,4-Benzenediamine, N-(4-aminophenyl)- used in cosmetics?
Yes, 1,4-Benzenediamine, N-(4-aminophenyl)- is also indexed as a cosmetic ingredient under the name 4,4'-Diaminodiphenylamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,4-Benzenediamine, N-(4-aminophenyl)- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,4-Benzenediamine, N-(4-aminophenyl)- used outside industrial chemicals?
1,4-Benzenediamine, N-(4-aminophenyl)- also appears in cosmetics, pharmaceutical databases.