Is 4-Amino-2-Nitrophenol ⚠️ safe in cosmetics?
4-Amino-2-Nitrophenol ⚠️ has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
4-Amino-2-Nitrophenol ⚠️
Also known as: Phenol, 4-amino-2-nitro-, 4-13-00-01284, C.I. Oxidation Base 25, 1-Amino-3-nitro-4-hydroxybenzene, p-Amino-o-nitrophenol (+15 more)
INCI: 4-AMINO-2-NITROPHENOL
4-Amino-2-Nitrophenol ⚠️ (CAS 119-34-6) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 119-34-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
4-Amino-2-Nitrophenol ⚠️ is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H335, H341).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-amino-2-nitrophenol
InChIKey
WHODQVWERNSQEO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not banned by FDA — still technically permitted under coal tar hair dye exemption, but CIR flagged concerns about potential carcinogenicity and mutagenicity.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Amino-2-Nitrophenol ⚠️.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 4-Amino-2-Nitrophenol ⚠️ across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
16, Sup 7
Evaluation Year
1987
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 412
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| BR | banned | - | - |
| CA | banned | - | - |
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 154.1
Log Kow: 0.96
Log Kp: -4.0655015487564325
Log Jmax: -8.117441878268611
Source: Roberts_Cheruvu_Mendeley_2022
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
4-Amino-2-nitrophenol | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
4-Amino-2-nitrophenol | TR-094: Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CASRN 119-34-6) (1978 ) | 04/26/78 | Clear Evidence | Equivocal Evidence | No Evidence | No Evidence | It is concluded that under the conditions of the bioassay, 4-amino-2-nitrophenol was carcinogenic for male Fischer 344 rats, inducing transitional-cell carcinomas of the urinary bladder; the t
Source: NTP Technical Reports
Evidence for Carcinogenicity
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 4-Amino-2-Nitrophenol ⚠️.
Regulatory Flags
prop65
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Phenol, 4-amino-2-nitro-
4-13-00-01284
C.I. Oxidation Base 25
1-Amino-3-nitro-4-hydroxybenzene
p-Amino-o-nitrophenol
BRN 1368435
CI Oxidation Base 25
EINECS 204-316-1
Fourrine 57
Fourrine Brown PR
Fourrine Brown Propyl
4-Hydroxy-3-nitroaniline
NCI-C03963
o-Nitro-p-aminophenol
2-Nitro-4-aminophenol
3-Nitro-4-hydroxyaniline
NSC 56809
ortho-Nitro-para-aminophenol
Oxidation Base 25
4-Amino-2-nitrofenol
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1516868
Frequently Asked Questions
Is 4-Amino-2-Nitrophenol ⚠️ allowed in the EU?
4-Amino-2-Nitrophenol ⚠️ EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Amino-2-Nitrophenol ⚠️ do in cosmetics?
4-Amino-2-Nitrophenol ⚠️ functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 119-34-6.
Is 4-Amino-2-Nitrophenol ⚠️ used outside cosmetics?
4-Amino-2-Nitrophenol ⚠️ also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 4-Amino-2-Nitrophenol ⚠️ have different safety status in cosmetics vs industrial chemicals?
4-Amino-2-Nitrophenol ⚠️ is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H335, H341).
Compliance Tools
Check 4-Amino-2-Nitrophenol ⚠️ compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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