Is Dihydrocoumarin safe in cosmetics?
Dihydrocoumarin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 6 toxicological study endpoint(s) are available in our database.
Dihydrocoumarin
Also known as: 2H-1-Benzopyran-2-one, 3,4-dihydro-, Hydrocoumarin, 5-17-10-00013, 1,2-Benzodihydropyrone, Benzopyranone, dihydro- (+15 more)
INCI: DIHYDROCOUMARIN
Dihydrocoumarin (CAS 119-84-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with sweet, coumarin-like odor. NOAEL 75 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 119-84-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with sweet, coumarin-like odor
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,4-dihydrochromen-2-one
InChIKey
VMUXSMXIQBNMGZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted with no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydrocoumarin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Dihydrocoumarin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 110 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
| NOAEL | 200 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS DB |
| NOAEL | 580 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
| NOAEL | 600 mg/kg bw/day | oral | rat | Chronic | COSMOS DB |
| NOAEL | 800 mg/kg bw/day | oral | mouse | Subchronic | COSMOS DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihydrocoumarin across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for Dihydrocoumarin based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: SCCS Opinion
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
6.5%
DPRA Lys %
13.56%
KeratinoSens IC50
1015 µM
hCLAT CV75
518.535 µg/mL
LLNA EC3
5.6%
NESIL
12960 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Ashby et al. (1995); DPRA: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Unilever commissioned, Charles River; KS: Joint Research Centre of the European Union 2014 | Unilever commissioned, Charles River; hCLAT: Nukada et al. 2011 [DOI:10.1111/j.1600-0536.2011.01952.x] | Unilever commissioned, IIVS; HPPT: [138] Kligman AM (1972): Report to RIFM, 25 August, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 12960 | - | - |
| HRIPT | - | 0 | 14173.23 | - | - |
| OECD_DA_Human | - | 0 | - | - | NA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 427
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics when used as fragrance ingredient |
| CA | banned | - | - |
| ASEAN | banned | - | All cosmetic products prohibited |
| KR | prohibited | - | - |
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2024-01-01.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | – | 7a (Deodorant – not spray) | – |
| 2 (Body spray) | – | 7b (Deodorant spray) | – |
| 3 (Body cream) | – | 8 (Face cream) | – |
| 4 (Fine fragrance) | – | 9 (Soap) | – |
| 5a (Body lotion) | – | 10a (Household – non-spray) | – |
| 5b (Face cream leave-on) | – | 10b (Household – spray) | – |
| 5c (Hand cream) | – | 11a (Intimate – leave-on) | – |
| 5d (Baby cream) | – | 11b (Intimate – rinse) | – |
| 6 (Mouthwash) | – | 12 (Not for consumer exposure) | – |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
3,4-Dihydrocoumarin | TR-423: Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1993 ) | 06/23/92 | Some Evidence | No Evidence | No Evidence | Some Evidence | Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of 3,4-dihydrocoumarin in male F344/N rats based on
Source: NTP Technical Reports
Regulatory (2)
JECFA Number
1171
Source: WHO/JECFA
JECFA Evaluation
MELILOTIC ACID LACTONE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/49 | FAS 52-JECFA 61/175
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
EU Banned in Cosmetics
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Dihydrocoumarin.
Regulatory Flags
potential-allergen
fragrance-component
eu_banned_cosmetics
ifra_fragrance
fda_food_additive
eu_cosing_listed
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dihydrocoumarin by CAS number or substance name.
Studies
6
Lowest NOAEL
110 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
COSMOS DB
Known Synonyms
2H-1-Benzopyran-2-one, 3,4-dihydro-
Hydrocoumarin
5-17-10-00013
1,2-Benzodihydropyrone
Benzopyranone, dihydro-
BRN 0004584
Chroman, 2-oxo-
Coumarin, 3,4-dihydro-
Dihydrobenzopyrone
3,4-Dyhydrocoumarin
EINECS 204-354-9
FEMA No. 2381
Hydrocinnamic acid, o-hydroxy-, delta-lactone
O-Hydroxycinnamic acid
Hydroxydihydrocinnamic acid lactone, o-
Melilotine
NCI-C55890
NSC 10121
UNII-NM5K1Y1BT2
2-chromanone
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
banned; Europe; Personal care
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIHYDROCOUMARIN
ChEMBL ID
CHEMBL89306
Frequently Asked Questions
Is Dihydrocoumarin allowed in the EU?
Dihydrocoumarin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydrocoumarin do in cosmetics?
Dihydrocoumarin functions as: Fragrance ingredient with sweet, coumarin-like odor. It is classified as a cosmetic ingredient in our database. CAS number: 119-84-6.
What is the NOAEL for Dihydrocoumarin?
The NOAEL (No Observed Adverse Effect Level) for Dihydrocoumarin is 110 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS DB.
Is Dihydrocoumarin used outside cosmetics?
Dihydrocoumarin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dihydrocoumarin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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