What is the NOAEL for 4-Amino-2-nitrophenol?
4-Amino-2-nitrophenol has 14 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.
NOAEL Data
IARC Group 3
Prop 65
Cosmetic Ingredient
4-Amino-2-nitrophenol
Also known as: Phenol, 4-amino-2-nitro-, 4-13-00-01284, C.I. Oxidation Base 25, 1-Amino-3-nitro-4-hydroxybenzene, p-Amino-o-nitrophenol (+15 more)
CAS 119-34-6
4-Amino-2-nitrophenol (CAS 119-34-6) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: California Proposition 65, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, CA Prop 65.
Cross-Vertical Regulatory Divergence
4-Amino-2-nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H335, H341).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4-Amino-2-nitrophenol
CAS Number
119-34-6
DTXSID
DTXSID6020064
Molecular Formula
C6H6N2O3
InChI Key
WHODQVWERNSQEO-UHFFFAOYSA-N
Monoisotopic Mass
154.037842
Synonyms
Phenol, 4-amino-2-nitro-4-13-00-01284C.I. Oxidation Base 251-Amino-3-nitro-4-hydroxybenzenep-Amino-o-nitrophenolBRN 1368435CI Oxidation Base 25EINECS 204-316-1Fourrine 57Fourrine Brown PRFourrine Brown Propyl4-Hydroxy-3-nitroaniline
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 16, Sup 7 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| N3499RCQ6B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N3499RCQ6B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N3499RCQ6B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N3499RCQ6B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =1470 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 2500 | ppm | Top dose | - | Mouse | NTP_ICE_cancer |
Showing 14 of 14 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1516868
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include 4-Amino-2-nitrophenol?
4-Amino-2-nitrophenol appears on 3 regulatory/inventory lists including banned; Europe; Personal care, OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
Is 4-Amino-2-nitrophenol a carcinogen according to IARC?
4-Amino-2-nitrophenol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is 4-Amino-2-nitrophenol on the California Proposition 65 list?
Yes, 4-Amino-2-nitrophenol is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is 4-Amino-2-nitrophenol used in cosmetics?
Yes, 4-Amino-2-nitrophenol is also indexed as a cosmetic ingredient under the name 2-Amino-4-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Amino-2-nitrophenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Amino-2-nitrophenol have different safety status in cosmetics vs industrial chemicals?
4-Amino-2-nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H335, H341).
Is 4-Amino-2-nitrophenol used outside industrial chemicals?
4-Amino-2-nitrophenol also appears in cosmetics, pharmaceutical databases.