Is 2-Amino-4-Nitrophenol safe in cosmetics?
2-Amino-4-Nitrophenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
2-Amino-4-Nitrophenol
Also known as: Phenol, 4-amino-2-nitro-, 4-13-00-01284, C.I. Oxidation Base 25, 1-Amino-3-nitro-4-hydroxybenzene, p-Amino-o-nitrophenol (+15 more)
INCI: 2-AMINO-4-NITROPHENOL
2-Amino-4-Nitrophenol (CAS 119-34-6) is a cosmetic cosmetic ingredient functioning as Hair dyeing. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 119-34-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Amino-4-Nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H335, H341).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-amino-2-nitrophenol
InChIKey
WHODQVWERNSQEO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
CIR concluded safe as a hair dye ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Amino-4-Nitrophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-Amino-4-Nitrophenol across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
16, Sup 7
Evaluation Year
1987
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 412
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| BR | banned | - | - |
| CA | banned | - | - |
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 154.1
Log Kow: 0.96
Log Kp: -4.0655015487564325
Log Jmax: -8.117441878268611
Source: Roberts_Cheruvu_Mendeley_2022
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
4-Amino-2-nitrophenol | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
4-Amino-2-nitrophenol | TR-094: Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CASRN 119-34-6) (1978 ) | 04/26/78 | Clear Evidence | Equivocal Evidence | No Evidence | No Evidence | It is concluded that under the conditions of the bioassay, 4-amino-2-nitrophenol was carcinogenic for male Fischer 344 rats, inducing transitional-cell carcinomas of the urinary bladder; the t
Source: NTP Technical Reports
Evidence for Carcinogenicity
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2-Amino-4-Nitrophenol.
Regulatory Flags
eu_banned_cosmetics
prop65
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Amino-4-Nitrophenol by CAS number or substance name.
Studies
24
Lowest NOAEL
0.001418 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Phenol, 4-amino-2-nitro-
4-13-00-01284
C.I. Oxidation Base 25
1-Amino-3-nitro-4-hydroxybenzene
p-Amino-o-nitrophenol
BRN 1368435
CI Oxidation Base 25
EINECS 204-316-1
Fourrine 57
Fourrine Brown PR
Fourrine Brown Propyl
4-Hydroxy-3-nitroaniline
NCI-C03963
o-Nitro-p-aminophenol
2-Nitro-4-aminophenol
3-Nitro-4-hydroxyaniline
NSC 56809
ortho-Nitro-para-aminophenol
Oxidation Base 25
4-Amino-2-nitrofenol
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1516868
Frequently Asked Questions
Is 2-Amino-4-Nitrophenol allowed in the EU?
2-Amino-4-Nitrophenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Amino-4-Nitrophenol do in cosmetics?
2-Amino-4-Nitrophenol functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 119-34-6.
Is 2-Amino-4-Nitrophenol used outside cosmetics?
2-Amino-4-Nitrophenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Amino-4-Nitrophenol have different safety status in cosmetics vs industrial chemicals?
2-Amino-4-Nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H335, H341).
Compliance Tools
Check 2-Amino-4-Nitrophenol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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4-Amino-2-Nitrophenol ⚠️
Poor
Chemical family
Hair Dyeing
Benzophenone
Poor
Chemical family
UV absorber, masking agent
Dihydrocoumarin
Good
Chemical family
Fragrance ingredient with sweet, coum...
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