Is Methyl Gentisate safe in cosmetics?
Methyl Gentisate has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Methyl Gentisate
Also known as: EINECS 218-427-8, UNII-LS28B004KM
INCI: METHYL DIHYDROXYBENZOATE
Methyl Gentisate (CAS 2150-46-1) is a cosmetic cosmetic ingredient functioning as Insufficient data available. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2150-46-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Methyl Gentisate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335, H400).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Insufficient data available
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
methyl 2,5-dihydroxybenzoate
InChIKey
XGDPKUKRQHHZTH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
CIR safety assessment does not exist
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Gentisate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Gentisate.
Regulatory Flags
EU Restricted
Known Synonyms
EINECS 218-427-8
UNII-LS28B004KM
Chemical Function
Chelating agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
METHYL 2,5-DIHYDROXYBENZOATE
ChEMBL ID
CHEMBL1978880
Frequently Asked Questions
Is Methyl Gentisate allowed in the EU?
Methyl Gentisate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Gentisate do in cosmetics?
Methyl Gentisate functions as: Insufficient data available. It is classified as a cosmetic ingredient in our database. CAS number: 2150-46-1.
Is Methyl Gentisate used outside cosmetics?
Methyl Gentisate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Methyl Gentisate have different safety status in cosmetics vs industrial chemicals?
Methyl Gentisate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335, H400).
Compliance Tools
Check Methyl Gentisate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Arginine
Excellent
Same category
Amino acid / pH Adjuster
D-Panthenol
Excellent
Same category
Hair and skin conditioning, humectant...
Dicaprylyl Ether
Excellent
Same category
Emollient
Emulsifying Wax
Excellent
Same category
O/W emulsifier; stabilizes oil-in-wat...
Ethyl Butyrate
Excellent
Same category
Perfuming, Masking
Fructose
Excellent
Same category
Humectant, Skin Conditioning, Flavori...
1,2,4-Benzenetriacetate
Poor
Similar safety
Hair dye precursor (triacetyl ester o...
1,2,4-Trihydroxybenzene
Poor
Similar safety
Hair colorant (auto-oxidative dye)
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Poor
Similar safety
Monomer / cross-linking agent used in...
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1,6-Hexamethylene Diisocyanate (HDI)
Poor
Similar safety
Monomer and crosslinker in polymer sy...
1,6-Hexanediamine
Poor
Similar safety
Industrial chemical (nylon monomer); ...
Methyl 2,4-Dihydroxybenzoate
Moderate
Chemical family
Skin Conditioning (maintains the skin...
Methyl Dihydroxybenzoate
Moderate
Chemical family
Chelating - binds metal ions that cou...
METHACRYLIC ACID/PEG-6 METHACRYLATE/PEG-6 DIMETHACRYLATE CROSSPOLYMER.
Good
Browse nearby
Film Forming
Is Methyl Gentisate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methyl Gentisate in your formulation.