What is the NOAEL for Methyl dihydroxybenzoate?
Methyl dihydroxybenzoate has 4 NOAEL studies in the database. The lowest reported value is LS28B004KM UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Methyl dihydroxybenzoate
Also known as: EINECS 218-427-8, UNII-LS28B004KM
CAS 2150-46-1
Methyl dihydroxybenzoate (CAS 2150-46-1) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Methyl dihydroxybenzoate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335, H400).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Methyl dihydroxybenzoate
CAS Number
2150-46-1
DTXSID
DTXSID80175841
Molecular Formula
C8H8O4
InChI Key
XGDPKUKRQHHZTH-UHFFFAOYSA-N
Monoisotopic Mass
168.042259
Synonyms
EINECS 218-427-8UNII-LS28B004KM
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Chelating agent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| LS28B004KM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LS28B004KM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LS28B004KM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LS28B004KM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl 2,5-dihydroxybenzoate | 218-427-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
METHYL 2,5-DIHYDROXYBENZOATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
Is Methyl dihydroxybenzoate used in cosmetics?
Yes, Methyl dihydroxybenzoate is also indexed as a cosmetic ingredient under the name Methyl Gentisate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methyl dihydroxybenzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Methyl dihydroxybenzoate have different safety status in cosmetics vs industrial chemicals?
Methyl dihydroxybenzoate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335, H400).
Is Methyl dihydroxybenzoate used outside industrial chemicals?
Methyl dihydroxybenzoate also appears in cosmetics, pharmaceutical databases.