Is Methyl Dihydroxybenzoate safe in cosmetics?
Methyl Dihydroxybenzoate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Methyl Dihydroxybenzoate
Also known as: EINECS 218-427-8, UNII-LS28B004KM
INCI: METHYL DIHYDROXYBENZOATE
Methyl Dihydroxybenzoate (CAS 2150-46-1) is a cosmetic cosmetic ingredient functioning as Chelating - binds metal ions that could negatively affect the stability or. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2150-46-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Methyl Dihydroxybenzoate is classified GHS Danger (H315, H317, H318, H319, H335, H400) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating - binds metal ions that could negatively affect the stability or appearance of cosmetics
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
methyl 2,5-dihydroxybenzoate
InChIKey
XGDPKUKRQHHZTH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
No specific prohibition or restriction; allowed under general cosmetic ingredient rules
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Dihydroxybenzoate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Dihydroxybenzoate.
Regulatory Flags
potential-allergen
Known Synonyms
EINECS 218-427-8
UNII-LS28B004KM
Chemical Function
Chelating agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
METHYL 2,5-DIHYDROXYBENZOATE
ChEMBL ID
CHEMBL1978880
Frequently Asked Questions
Is Methyl Dihydroxybenzoate allowed in the EU?
Methyl Dihydroxybenzoate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Dihydroxybenzoate do in cosmetics?
Methyl Dihydroxybenzoate functions as: Chelating - binds metal ions that could negatively affect the stability or appearance of cosmetics. It is classified as a cosmetic ingredient in our database. CAS number: 2150-46-1.
Is Methyl Dihydroxybenzoate used outside cosmetics?
Methyl Dihydroxybenzoate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Methyl Dihydroxybenzoate have different safety status in cosmetics vs industrial chemicals?
Methyl Dihydroxybenzoate is classified GHS Danger (H315, H317, H318, H319, H335, H400) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Methyl Dihydroxybenzoate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Methyl 2,4-Dihydroxybenzoate
Moderate
Chemical family
Skin Conditioning (maintains the skin...
Methyl Gentisate
Poor
Chemical family
Insufficient data available
METHACRYLIC ACID/PEG-6 METHACRYLATE/PEG-6 DIMETHACRYLATE CROSSPOLYMER.
Good
Browse nearby
Film Forming
Is Methyl Dihydroxybenzoate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methyl Dihydroxybenzoate in your formulation.