Is Acid Orange 3 safe in cosmetics?
Acid Orange 3 has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Acid Orange 3
Also known as: Acid Fast Yellow E5R, Acid Leather Light Brown G, 2-Anilino-5-(2,4-dinitroanilino)benzenesulfonic acid sodium salt, Coranil Brown H EPS, Dimacide Yellow N-5RL (+15 more)
INCI: ACID ORANGE 3
Acid Orange 3 (CAS 6373-74-6) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. Reported NOAEL =1000 mg/kg bw/day in Mouse (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6373-74-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Acid Orange 3 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
sodium 2-anilino-5-(2,4-dinitroanilino)benzenesulfonate
InChIKey
KKBFCPLWFWQNFB-UHFFFAOYSA-M
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not FDA-approved; not listed for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Orange 3.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Acid Orange 3. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Mouse | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =1500 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
3 February 2000
Verdict: safe
ion can avoid significant exposure. Accordingly, the Expert Panel concluded that Acid Orange 3 is safe for use in hair dye formulations at concentrations less than or equal to 0.2%. INTRODUCTION Acid Orange 3 is a nitro color that functions as a hair colorant in hair dyes and colors (Wenninger, C
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
57
Evaluation Year
1992
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
C.I. Acid Orange 3 | TR-335: Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1988 ) | 07/14/87 | No Evidence | Clear Evidence | No Evidence | No Evidence | Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenic activity of C.I. Acid Orange 3 for male F344/N rats administered
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of CI Acid Orange 3. There is limited evidence in experimental animals for the carcinogenicity of CI Acid Orange 3. Overall evaluation: CI Acid Orange 3 is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Acid Orange 3.
Regulatory Flags
potential-allergen
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Orange 3 by CAS number or substance name.
Studies
2
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Acid Fast Yellow E5R
Acid Leather Light Brown G
2-Anilino-5-(2,4-dinitroanilino)benzenesulfonic acid sodium salt
Coranil Brown H EPS
Dimacide Yellow N-5RL
5-((2,4-Dinitrophenyl)amino)-2-(phenylamino)benzenesulfonic acid monosodium salt
Duasyn Acid Yellow RRT
EINECS 228-921-5
Elbenyl Orange A-3RD
Erio Yellow AEN
Heliacid Light Yellow 4R
Intranyl Orange T-4R
Lanaperl Yellow Brown GT
Nailamide Yellow Brown E-L
NCI-C54911
Nylocrom Yellow 3R
Nylosan Yellow E-3R
Polan Yellow E-3R
Sellacid Yellow AEN
Solanile Yellow E
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3181851
Frequently Asked Questions
Is Acid Orange 3 allowed in the EU?
Acid Orange 3 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Orange 3 do in cosmetics?
Acid Orange 3 functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 6373-74-6.
What is the NOAEL for Acid Orange 3?
The NOAEL (No Observed Adverse Effect Level) for Acid Orange 3 is =1000 mg/kg bw/day based on a short-term study via oral route in Mouse. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Acid Orange 3 used outside cosmetics?
Acid Orange 3 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acid Orange 3 have different safety status in cosmetics vs industrial chemicals?
Acid Orange 3 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335).
Compliance Tools
Check Acid Orange 3 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Poor
Similar safety
Monomer / cross-linking agent used in...
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1,6-Hexamethylene Diisocyanate (HDI)
Poor
Similar safety
Monomer and crosslinker in polymer sy...
1,6-Hexanediamine
Poor
Similar safety
Industrial chemical (nylon monomer); ...
1-Nitropropane
Poor
Similar safety
None in cosmetics - industrial solven...
2,2'-Thiobis(4-Chlorophenol)
Poor
Similar safety
Antimicrobial / antifungal agent
ACID RED 27
Moderate
Browse nearby
Hair Dyeing
ACID RED 51
Moderate
Browse nearby
Colorant, Hair Dyeing
ACORUS CALAMUS ROOT EXTRACT
Good
Browse nearby
Perfuming, Skin Conditioning
Is Acid Orange 3 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Acid Orange 3 in your formulation.