NOAEL Studies Cosmetic Ingredient

Acid Orange 3 NOAEL Studies

INCI: ACID ORANGE 3

CAS: 6373-74-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1992 IARC Monographs {"additional_info":"volume_publication_year=1993","evaluation_year":1992,"source_table":"iarc_classifications","volume":"57"}
NTP_ICE_cancer 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=1459; Record_ID=cancer_2994; Data_Type=WOE; Formulation_Name=C.I. Acid Orange 3; Mixture=Chemical; DTXSID=DTXSID1021081; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/75; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021081; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021081
NTP_ICE_cancer Top dose 500 mg/kg bw/day Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1453; Record_ID=cancer_2992; Data_Type=In Vivo; Formulation_Name=C.I. Acid Orange 3; Mixture=Chemical; DTXSID=DTXSID1021081; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=500; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-335; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr335/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021081; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021081
NTP_ICE_cancer Top dose 250 mg/kg bw/day Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1455; Record_ID=cancer_2991; Data_Type=In Vivo; Formulation_Name=C.I. Acid Orange 3; Mixture=Chemical; DTXSID=DTXSID1021081; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=250; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-335; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr335/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021081; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021081
NTP_ICE_cancer Top dose 750 mg/kg bw/day Rat Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1458; Record_ID=cancer_2993; Data_Type=In Vivo; Formulation_Name=C.I. Acid Orange 3; Mixture=Chemical; DTXSID=DTXSID1021081; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=750; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-335; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr335/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021081; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021081
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >375 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4380; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11301/7/8?documentUUID=dc7ef4ba-67b8-4d3c-952b-74d617acf7c7; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820487:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_da8eb9eec28c60bb2e28c0a989f25bb4
ToxValDB_ECHA_IUCLID NOAEL >200 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4383; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11301/7/8?documentUUID=dc7ef4ba-67b8-4d3c-952b-74d617acf7c7; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820488:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c8c04aca3d850b10cbdb7dcc444c8d37
ToxValDB_ECHA_IUCLID NOAEL >500 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4383; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11301/7/8?documentUUID=dc7ef4ba-67b8-4d3c-952b-74d617acf7c7; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820489:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8279756ab15ca1eb72c6e7df37588403
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Mouse oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb85e4b0a7c65d2266ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11301/7/6/2?documentUUID=dc7ef4ba-67b8-4d3c-952b-74d617acf7c7; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=clinical signs|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15849672:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6408c4ef1ba0ac1e2d5f02a2bc325d52
ToxValDB_ECHA_IUCLID NOAEL =1500 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb85e4b0a7c65d2266c0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11301/7/6/2?documentUUID=dc7ef4ba-67b8-4d3c-952b-74d617acf7c7; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=clinical signs|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15849673:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6dd65a395791e1e75cbbbb703b391f50
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOEL =750 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e0be4b0a676289df2d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Body Weight Changes: decrease|Histopathology: Kidney-Nephrosis Kidney-Suppurative inflammation Kidney/Renal papilla - Necrosis Urinary bladder/Transitional epithelium - Acidophilic cytoplasmic body Urinary bladder/Transitional epithelium - Hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=HESS:15638435:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_74da529b1bf6c0afe58089ab5e510ce5
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier P0XV7XM57J UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N4O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P0XV7XM57J"}
openFDA substances FDA UNII substance identifier P0XV7XM57J UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N4O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P0XV7XM57J"}
openFDA substances FDA UNII substance identifier P0XV7XM57J UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N4O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P0XV7XM57J"}
openFDA substances FDA UNII substance identifier P0XV7XM57J UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N4O7S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P0XV7XM57J"}