What is the NOAEL for C.I. Acid Orange 3?
C.I. Acid Orange 3 has 15 NOAEL studies in the database. The lowest reported value is P0XV7XM57J UNII. Source: openFDA substances.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
C.I. Acid Orange 3
Also known as: Acid Fast Yellow E5R, Acid Leather Light Brown G, 2-Anilino-5-(2,4-dinitroanilino)benzenesulfonic acid sodium salt, Coranil Brown H EPS, Dimacide Yellow N-5RL (+15 more)
CAS 6373-74-6
C.I. Acid Orange 3 (CAS 6373-74-6) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Acid Orange 3 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
C.I. Acid Orange 3
CAS Number
6373-74-6
DTXSID
DTXSID1021081
Molecular Formula
C18H14N4O7S.Na
InChI Key
KKBFCPLWFWQNFB-UHFFFAOYSA-M
Synonyms
Acid Fast Yellow E5RAcid Leather Light Brown G2-Anilino-5-(2,4-dinitroanilino)benzenesulfonic acid sodium saltCoranil Brown H EPSDimacide Yellow N-5RL5-((2,4-Dinitrophenyl)amino)-2-(phenylamino)benzenesulfonic acid monosodium saltDuasyn Acid Yellow RRTEINECS 228-921-5Elbenyl Orange A-3RDErio Yellow AENHeliacid Light Yellow 4RIntranyl Orange T-4R
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1992 | 57 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| P0XV7XM57J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P0XV7XM57J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P0XV7XM57J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P0XV7XM57J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >200 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >375 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >500 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =750 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 250 | mg/kg bw/day | Top dose | Gavage | Mouse | NTP_ICE_cancer |
| 500 | mg/kg bw/day | Top dose | Gavage | Mouse | NTP_ICE_cancer |
| 750 | mg/kg bw/day | Top dose | Gavage | Rat | NTP_ICE_cancer |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 2-anilino-5-(2,4-dinitroanilino)benzenesulphonate | 228-921-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3181851
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include C.I. Acid Orange 3?
C.I. Acid Orange 3 appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is C.I. Acid Orange 3 a carcinogen according to IARC?
C.I. Acid Orange 3 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is C.I. Acid Orange 3 used in cosmetics?
Yes, C.I. Acid Orange 3 is also indexed as a cosmetic ingredient under the name Acid Orange 3. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Acid Orange 3 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Acid Orange 3 have different safety status in cosmetics vs industrial chemicals?
C.I. Acid Orange 3 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H318, H319, H335).
Is C.I. Acid Orange 3 used outside industrial chemicals?
C.I. Acid Orange 3 also appears in cosmetics, pharmaceutical databases.