Is 2,4-Diaminodiphenylamine safe in cosmetics?
2,4-Diaminodiphenylamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
2,4-Diaminodiphenylamine
Also known as: 3-13-00-00552, BRN 1964383, Diphenylamine, 2,4-diamino-, NSC 401132, N(sup 1)-Phenyl-1,2,4-benzenetriamine (+1 more)
INCI: 2,4-DIAMINODIPHENYLAMINE
2,4-Diaminodiphenylamine (CAS 136-17-4) is a cosmetic cosmetic ingredient functioning as Hair dye (oxidative). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 136-17-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,4-Diaminodiphenylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H331, H319, H373, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dye (oxidative)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1-N-phenylbenzene-1,2,4-triamine
InChIKey
VOSLIUIVGWBSOK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not specifically authorized; falls under coal tar hair dye caution labeling if used
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,4-Diaminodiphenylamine.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1214
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2,4-Diaminodiphenylamine.
Regulatory Flags
potential-allergen
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
3-13-00-00552
BRN 1964383
Diphenylamine, 2,4-diamino-
NSC 401132
N(sup 1)-Phenyl-1,2,4-benzenetriamine
UNII-45DN363J8C
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1241074
Frequently Asked Questions
Is 2,4-Diaminodiphenylamine allowed in the EU?
2,4-Diaminodiphenylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,4-Diaminodiphenylamine do in cosmetics?
2,4-Diaminodiphenylamine functions as: Hair dye (oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 136-17-4.
Is 2,4-Diaminodiphenylamine used outside cosmetics?
2,4-Diaminodiphenylamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,4-Diaminodiphenylamine have different safety status in cosmetics vs industrial chemicals?
2,4-Diaminodiphenylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H331, H319, H373, H400, H410).
Compliance Tools
Check 2,4-Diaminodiphenylamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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