Is Vanillylmandelic Acid safe in cosmetics?
Vanillylmandelic Acid has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Vanillylmandelic Acid
Also known as: Benzeneacetic acid, α,4-dihydroxy-3-methoxy-, Mandelic acid, 4-hydroxy-3-methoxy-, α,4-Dihydroxy-3-methoxybenzeneacetic acid, Vanillomandelic acid, Vanilmandelic acid (+14 more)
INCI: VANILLYLMANDELIC ACID
Vanillylmandelic Acid (CAS 55-10-7) is a cosmetic cosmetic ingredient functioning as Clinical Diagnostic Marker. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 55-10-7 →
Auto-generated CPSR Part A draft with source citations
Function
Clinical Diagnostic Marker
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
InChIKey
CGQCWMIAEPEHNQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS for food flavoring only (FEMA 4660). Not used in cosmetics.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Vanillylmandelic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
2020
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
Hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/114 | FAS 64-JECFA 73/207
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Vanillylmandelic Acid.
Regulatory Flags
fda_food_additive
Known Synonyms
Benzeneacetic acid, α,4-dihydroxy-3-methoxy-
Mandelic acid, 4-hydroxy-3-methoxy-
α,4-Dihydroxy-3-methoxybenzeneacetic acid
Vanillomandelic acid
Vanilmandelic acid
Vanillinmandelic acid
4′-Hydroxy-3′-methoxymandelic acid
DL-Vanillylmandelic acid
4-Hydroxy-3-methoxy-DL-mandelic acid
DL-Vanillomandelic acid
Vanillyl-dl-mandelic acid
(4-Hydroxy-3-methoxyphenyl)glycolic acid
3-Methoxy-4-hydroxyphenylhydroxyacetic acid
(+/-)-3-Methoxy-4-hydroxymandelic acid
(+/-)-4-Hydroxy-3-methoxymandelic acid
(+/-)-Vanilmandelic acid
2-(4′-Hydroxy-3′-methoxyphenyl)-2-hydroxyethanoic acid
HMMA
DL-4-Hydroxy-3-methoxymandelic acid
Chemical Function
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1256396
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
HYDROXY(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Vanillylmandelic Acid allowed in the EU?
Vanillylmandelic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Vanillylmandelic Acid do in cosmetics?
Vanillylmandelic Acid functions as: Clinical Diagnostic Marker. It is classified as a cosmetic ingredient in our database. CAS number: 55-10-7.
Is Vanillylmandelic Acid used outside cosmetics?
Vanillylmandelic Acid also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Vanillylmandelic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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