Is Phenethyl Isothiocyanate safe in cosmetics?
Phenethyl Isothiocyanate has a safety rating of "POOR" in our database. EU status: permitted. US status: restricted.
Poor
Cosmetic Ingredient
Phenethyl Isothiocyanate
Also known as: Benzene, (2-isothiocyanatoethyl)-, 2-Phenylethyl isothiocyanate, Phenylethyl isothiocyanate, 4-12-00-02476, BRN 2084162 (+9 more)
INCI: PHENETHYL ISOTHIOCYANATE
Phenethyl Isothiocyanate (CAS 2257-09-2) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming agent). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2257-09-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (perfuming agent)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-isothiocyanatoethylbenzene
InChIKey
IZJDOKYDEWTZSO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Primarily studied as chemopreventive agent (PEITC); not specifically restricted by FDA for cosmetic use, but limited cosmetic precedent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenethyl Isothiocyanate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1563
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PHENETHYL ISOTHIOCYANATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">TRS 934-JECFA 65/64 | ">FAS 60-JECFA 69/629
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Phenethyl Isothiocyanate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Benzene, (2-isothiocyanatoethyl)-
2-Phenylethyl isothiocyanate
Phenylethyl isothiocyanate
4-12-00-02476
BRN 2084162
EINECS 218-855-5
NSC 87868
Phenylethyl mustard oil
UNII-6U7TFK75KV
(2-Isothiocyanatoethyl)benzene
PEITC
Phenylaethylsenfoel
beta-phenethyl isothiocyanate
beta-phenylethyl isothiocyanate
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PHENETHYLISOTHIOCYANATE
ChEMBL ID
CHEMBL151649
Frequently Asked Questions
Is Phenethyl Isothiocyanate allowed in the EU?
Phenethyl Isothiocyanate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Isothiocyanate do in cosmetics?
Phenethyl Isothiocyanate functions as: Fragrance (perfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 2257-09-2.
Is Phenethyl Isothiocyanate used outside cosmetics?
Phenethyl Isothiocyanate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenethyl Isothiocyanate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Preservative
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