Is Acetoin safe in cosmetics?
Acetoin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Acetoin
Also known as: 2-01-00-00870, Acethoin, BRN 0385636, EINECS 208-174-1, FEMA No. 2008 (+13 more)
INCI: ACETOIN
Acetoin (CAS 513-86-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning, fragrance. NOAEL 90 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 513-86-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Acetoin is classified GHS Danger (H226, H228, H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning, fragrance
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS as food flavoring; permitted in cosmetics without restriction. RIFM safety assessment completed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetoin.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Acetoin across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
GROUP; SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fermentation
{"cas_number": "varies", "ingredient_class": "microbial_metabolite", "production_organism": "bacteria", "fermentation_type": "aerobic", "substrate_feedstock": "glucose, amino acids", "bioactive_compounds_produced": "Acetoin", "mechanism_of_action_skin": "cell signaling, antimicrobial, antioxidant, metabolic regulation", "skin_benefit_primary": "antioxidant", "skin_benefit_secondary": "anti_inflamm…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Acetoin.
Regulatory Flags
fragrance-component
natural-origin
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
2-01-00-00870
Acethoin
BRN 0385636
EINECS 208-174-1
FEMA No. 2008
UNII-BG4D34CO2H
(R)-2-acetoin
(R)-3-hydroxy-2-butanone
(R)-3-hydroxybutan-2-one
(R)-acetoin
(R)-dimethylketol
(S)-2-Acetoin
2-Butanol-3-one
2-Hydroxy-3-oxobutane
3-Hydroxyl-2-butanone
b-Oxobutane
beta-Oxobutane
gamma-Hydroxy-beta-oxobutane
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Canada; pharmaceutical
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561873
Frequently Asked Questions
Is Acetoin allowed in the EU?
Acetoin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetoin do in cosmetics?
Acetoin functions as: Skin conditioning, fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 513-86-0.
Is Acetoin used outside cosmetics?
Acetoin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acetoin have different safety status in cosmetics vs industrial chemicals?
Acetoin is classified GHS Danger (H226, H228, H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Acetoin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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