Is Hydroxypropyl Beta-Cyclodextrin safe in cosmetics?
Hydroxypropyl Beta-Cyclodextrin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Hydroxypropyl Beta-Cyclodextrin
Also known as: β-Cyclodextrin, 2-hydroxypropyl ethers, 5,10,15,25-tetrakis(hydroxymethyl)-40,44,47,49-tetrakis(2-hydroxypropoxy)-20,30,35-tris[(2-hydroxypropoxy)methyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}.2^{23,26}.2^{28,31}]nonatetracontane-36,37,38,39,41,42,43,45,46,48-decol, EC No.: 420-920-1, 2-Hydroxypropyl-.beta.-cyclodextrine ethers, C'Cavitron 82006 (+9 more)
INCI: HYDROXYPROPYL BETA-CYCLODEXTRIN
Hydroxypropyl Beta-Cyclodextrin (CAS 128446-35-5) is a cosmetic cosmetic ingredient functioning as Encapsulant; highly water-soluble inclusion complex former; solubilizer for. Reported NOAEL =1000 mg/kg bw/day in Rabbit (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 128446-35-5 →
Auto-generated CPSR Part A draft with source citations
Function
Encapsulant; highly water-soluble inclusion complex former; solubilizer for poorly water-soluble cosmetic actives; stabilizer
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel concluded safe as used in cosmetics (October 2015). Not subject to FDA restriction. Parent beta-cyclodextrin has FDA GRAS status for food; HP-beta-CD is an approved USP/NF excipient.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxypropyl Beta-Cyclodextrin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Hydroxypropyl Beta-Cyclodextrin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rabbit | developmental | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
deodorant
{"cas_number": "128446-35-5", "ingredient_class": "odor_absorber", "mechanism_of_action": "odor_absorption", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "12-24", "odor_reduction_pct": "50-70", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies",…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxypropyl Beta-Cyclodextrin.
Regulatory Flags
low-penetration
chelating-agent
excipient
cir-assessed
ema-reviewed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Hydroxypropyl Beta-Cyclodextrin by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
β-Cyclodextrin, 2-hydroxypropyl ethers
5,10,15,25-tetrakis(hydroxymethyl)-40,44,47,49-tetrakis(2-hydroxypropoxy)-20,30,35-tris[(2-hydroxypropoxy)methyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}.2^{23,26}.2^{28,31}]nonatetracontane-36,37,38,39,41,42,43,45,46,48-decol
EC No.: 420-920-1
2-Hydroxypropyl-.beta.-cyclodextrine ethers
C'Cavitron 82006
CD-B
Cavasol W7 HP
Cavamax W7 HP
Hydroxy propyl beta-cyclodextrin
Kleptose HP
TN-9502
EEC No.: 420-920-1
ELINCS 420-920-1
420-920-1
Chemical Function
Deodorizer
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ADRABETADEX
ChEMBL ID
CHEMBL4297678
Max Phase
3
Frequently Asked Questions
Is Hydroxypropyl Beta-Cyclodextrin allowed in the EU?
Hydroxypropyl Beta-Cyclodextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxypropyl Beta-Cyclodextrin do in cosmetics?
Hydroxypropyl Beta-Cyclodextrin functions as: Encapsulant; highly water-soluble inclusion complex former; solubilizer for poorly water-soluble cosmetic actives; stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 128446-35-5.
What is the NOAEL for Hydroxypropyl Beta-Cyclodextrin?
The NOAEL (No Observed Adverse Effect Level) for Hydroxypropyl Beta-Cyclodextrin is =1000 mg/kg bw/day based on a developmental study via oral route in Rabbit. Source: ECHA.
Is Hydroxypropyl Beta-Cyclodextrin used outside cosmetics?
Hydroxypropyl Beta-Cyclodextrin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydroxypropyl Beta-Cyclodextrin compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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