Is Hydroxyethyl Cyclodextrin safe in cosmetics?
Hydroxyethyl Cyclodextrin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hydroxyethyl Cyclodextrin
INCI: HYDROXYETHYL CYCLODEXTRIN
Hydroxyethyl Cyclodextrin (CAS 128446-32-2) is a cosmetic cosmetic ingredient functioning as Complexing agent, solubilizer, stabilizer. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 128446-32-2 →
Auto-generated CPSR Part A draft with source citations
Function
Complexing agent, solubilizer, stabilizer
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30S,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-37,39,41,43,45,47,49-heptakis(2-hydroxyethoxy)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38,40,42,44,46,48-heptol
InChIKey
PCWPQSDFNIFUPO-KCVBUHIQSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR; no CIR final report as standalone ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyethyl Cyclodextrin.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxyethyl Cyclodextrin.
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hydroxyethyl Cyclodextrin allowed in the EU?
Hydroxyethyl Cyclodextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyethyl Cyclodextrin do in cosmetics?
Hydroxyethyl Cyclodextrin functions as: Complexing agent, solubilizer, stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 128446-32-2.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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