NOAEL Studies Cosmetic Ingredient

Hydroxypropyl Beta-Cyclodextrin NOAEL Studies

INCI: HYDROXYPROPYL BETA-CYCLODEXTRIN

CAS: 128446-35-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >2.95 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1861; Record_ID=acute_inhalation_2450; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID20894281; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.95; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27504/7/3/3/?documentUUID=cf1bff7a-5b50-483e-8d64-7b20bfdb2b0c; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894281
NTP ICE acute inhalation LC50 >=4.9 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1862; Record_ID=acute_inhalation_2497; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID20894281; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>=; Response=4.9; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27504/7/3/3/?documentUUID=f69e9e72-00b1-4e2c-ac24-1adcd27cc2a2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894281
ECHA 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEC =100 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14017/7/6/3?documentUUID=c519dfb5-fbcf-4d62-bc66-2b619296cba4; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827878_15827879_15827880:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a6f052bc618d85b676be4196dc72c1c
ECHA LOEL =500 mg/kg bw/day Rat oral chronic; 93 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2d19; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14017/7/6/2?documentUUID=c519dfb5-fbcf-4d62-bc66-2b619296cba4; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=clinical biochemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECHA IUCLID:15847602:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a11b9153e7d4b188d082d5f985b080e
ECHA NOAEC =10 mg/m3 Rat inhalation - short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fa0e4b096bca877e32a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14017/7/6/3?documentUUID=66dab70e-0874-46c9-8777-ff811b8f6b92; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826945_15826946:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9689d71dfe265316cc4c25590d203e7c
ECHA NOAEC =1000 mg/m3 Rat inhalation - short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fa0e4b096bca877e32a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14017/7/6/3?documentUUID=66dab70e-0874-46c9-8777-ff811b8f6b92; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826945_15826946:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44f2b1aa1f597eb00076d2f7d20ee01f
ECHA NOAEL <500 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc23a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14017/7/9/3?documentUUID=c519dfb5-fbcf-4d62-bc66-2b619296cba4; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15823472:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_47de8d5cbfcc37d7cba2d4c8b3aec3eb
ECHA NOAEL =1000 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc23a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14017/7/9/3?documentUUID=c519dfb5-fbcf-4d62-bc66-2b619296cba4; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823290:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b06321a6b871b7bf261ca53498d73d5b
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1I96OHX6EK UNII - - - chemical {"approval_status":null,"molecular_formula":"C60H106O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1I96OHX6EK"}
openFDA substances FDA UNII substance identifier 1I96OHX6EK UNII - - - chemical {"approval_status":null,"molecular_formula":"C60H106O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1I96OHX6EK"}
openFDA substances FDA UNII substance identifier 1I96OHX6EK UNII - - - chemical {"approval_status":null,"molecular_formula":"C60H106O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1I96OHX6EK"}
openFDA substances FDA UNII substance identifier 1I96OHX6EK UNII - - - chemical {"approval_status":null,"molecular_formula":"C60H106O40","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1I96OHX6EK"}
openFDA substances FDA UNII substance identifier 8W6Q67R6NX UNII - - - chemical {"approval_status":null,"molecular_formula":"C54H94O38","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8W6Q67R6NX"}
openFDA substances FDA UNII substance identifier 8W6Q67R6NX UNII - - - chemical {"approval_status":null,"molecular_formula":"C54H94O38","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8W6Q67R6NX"}
openFDA substances FDA UNII substance identifier 8W6Q67R6NX UNII - - - chemical {"approval_status":null,"molecular_formula":"C54H94O38","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8W6Q67R6NX"}
openFDA substances FDA UNII substance identifier 8W6Q67R6NX UNII - - - chemical {"approval_status":null,"molecular_formula":"C54H94O38","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8W6Q67R6NX"}