What is the NOAEL for 2-Hydroxypropyl-beta-cyclodextrin?
2-Hydroxypropyl-beta-cyclodextrin has 16 NOAEL studies in the database. The lowest reported value is 1I96OHX6EK UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Hydroxypropyl-beta-cyclodextrin
Also known as: β-Cyclodextrin, 2-hydroxypropyl ethers, 5,10,15,25-tetrakis(hydroxymethyl)-40,44,47,49-tetrakis(2-hydroxypropoxy)-20,30,35-tris[(2-hydroxypropoxy)methyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}.2^{23,26}.2^{28,31}]nonatetracontane-36,37,38,39,41,42,43,45,46,48-decol, EC No.: 420-920-1, 2-Hydroxypropyl-.beta.-cyclodextrine ethers, C'Cavitron 82006 (+9 more)
CAS 128446-35-5
2-Hydroxypropyl-beta-cyclodextrin (CAS 128446-35-5) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Hydroxypropyl Beta-Cyclodextrin — Deep Resear →
SOURCE
NOAEL studies
NOAEL studies
16
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
2-Hydroxypropyl-beta-cyclodextrin
CAS Number
128446-35-5
DTXSID
DTXSID20894281
Synonyms
β-Cyclodextrin, 2-hydroxypropyl ethers5,10,15,25-tetrakis(hydroxymethyl)-40,44,47,49-tetrakis(2-hydroxypropoxy)-20,30,35-tris[(2-hydroxypropoxy)methyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2^{3,6}.2^{8,11}.2^{13,16}.2^{18,21}.2^{23,26}.2^{28,31}]nonatetracontane-36,37,38,39,41,42,43,45,46,48-decolEC No.: 420-920-12-Hydroxypropyl-.beta.-cyclodextrine ethersC'Cavitron 82006CD-BCavasol W7 HPCavamax W7 HPHydroxy propyl beta-cyclodextrinKleptose HPTN-9502EEC No.: 420-920-1
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
DeodorizerSoftener and conditioner
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1I96OHX6EK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I96OHX6EK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I96OHX6EK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I96OHX6EK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8W6Q67R6NX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8W6Q67R6NX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8W6Q67R6NX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8W6Q67R6NX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2.95 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >=4.9 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =100 | mg/m3 | LOAEC | inhalation | Rat | ECHA |
| =500 | mg/kg bw/day | LOEL | oral | Rat | ECHA |
| =10 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| =1000 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| <500 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =1000 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-Hydroxypropyl-β-cyclodextrine ethers | 420-920-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
2%
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ADRABETADEX
ChEMBL Phase
3
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 2-Hydroxypropyl-beta-cyclodextrin used in cosmetics?
Yes, 2-Hydroxypropyl-beta-cyclodextrin is also indexed as a cosmetic ingredient under the name Hydroxypropyl Beta-Cyclodextrin — Deep Resear. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Hydroxypropyl-beta-cyclodextrin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Hydroxypropyl-beta-cyclodextrin used outside industrial chemicals?
2-Hydroxypropyl-beta-cyclodextrin also appears in cosmetics, pharmaceutical databases.