Is Hexene (1-Hexene) safe in cosmetics?
Hexene (1-Hexene) has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted. 2 toxicological study endpoint(s) are available in our database.
Hexene (1-Hexene)
Also known as: 1-n-Hexene, UN 2370 (DOT), Dialen 6, Linealene 6, α-Hexene (+7 more)
INCI: HEXENE
Hexene (1-Hexene) (CAS 592-41-6) is a cosmetic cosmetic ingredient functioning as Fragrance component (IFRA listed) or solvent/process residual. Reported NOAEL =350 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 592-41-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hexene (1-Hexene) is classified GHS Danger (H225, H304, H319, H335, H336, H401) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance component (IFRA listed) or solvent/process residual
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
hex-1-ene
InChIKey
LIKMAJRDDDTEIG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Not specifically restricted under 21 CFR for cosmetics; no CIR review; general safety falls under FDA's adulteration provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexene (1-Hexene).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Hexene (1-Hexene). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =350 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1010 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is mildly irritating to the eyes and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure at high levels could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0490
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
A low moderate irritant to the skin and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Monomers
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Hexene (1-Hexene).
Regulatory Flags
fragrance-component
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Hexene (1-Hexene) by CAS number or substance name.
Studies
17
Lowest NOAEL
101 mg/kg bw/day
Highest NOAEL
1010 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
1-n-Hexene
UN 2370 (DOT)
Dialen 6
Linealene 6
α-Hexene
Hex-1-ene
Hex-1-en
hex-1-eno
1-Hexeno
Butylethylene
EINECS 209-753-1
UNII-B38ZZ8C206
Chemical Function
Solvent
Monomers
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1548726
Frequently Asked Questions
Is Hexene (1-Hexene) allowed in the EU?
Hexene (1-Hexene) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexene (1-Hexene) do in cosmetics?
Hexene (1-Hexene) functions as: Fragrance component (IFRA listed) or solvent/process residual. It is classified as a cosmetic ingredient in our database. CAS number: 592-41-6.
What is the NOAEL for Hexene (1-Hexene)?
The NOAEL (No Observed Adverse Effect Level) for Hexene (1-Hexene) is =350 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Hexene (1-Hexene) used outside cosmetics?
Hexene (1-Hexene) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hexene (1-Hexene) have different safety status in cosmetics vs industrial chemicals?
Hexene (1-Hexene) is classified GHS Danger (H225, H304, H319, H335, H336, H401) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Hexene (1-Hexene) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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