NOAEL Data REACH Registered Cosmetic Ingredient

1-Hexene

Also known as: 1-n-Hexene, UN 2370 (DOT), Dialen 6, Linealene 6, α-Hexene (+8 more)

CAS 592-41-6

1-Hexene (CAS 592-41-6) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Hexene (1-Hexene) →

Cross-Vertical Regulatory Divergence

1-Hexene is classified GHS Danger (H225, H304, H319, H335, H336, H401) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

1-Hexene

CAS Number

592-41-6

DTXSID

DTXSID4025402

Molecular Formula

C6H12

InChI Key

LIKMAJRDDDTEIG-UHFFFAOYSA-N

Monoisotopic Mass

84.0939

Synonyms

1-n-HexeneUN 2370 (DOT)Dialen 6Linealene 6α-HexeneHex-1-eneHex-1-enhex-1-eno1-HexenoButylethyleneEINECS 209-753-1UNII-B38ZZ8C206

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is mildly irritating to the eyes and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure at high levels could cause lowering of consciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
ACGIH	TWA	50 ppm [1999]	50	-	N
CAL/OSHA	TWA	50 ppm (180 mg/m³)	50	180	N
AIHA	ERPG-1	--	-	-	-
AIHA	ERPG-2	500 ppm	500	-	-
AIHA	ERPG-3	5000 ppm	5000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

SolventMonomers

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 10 of 10 studies

Value	Unit	Endpoint	Route	Species	Source
B38ZZ8C206	UNII	FDA UNII substance identifier	-	-	openFDA substances
B38ZZ8C206	UNII	FDA UNII substance identifier	-	-	openFDA substances
B38ZZ8C206	UNII	FDA UNII substance identifier	-	-	openFDA substances
B38ZZ8C206	UNII	FDA UNII substance identifier	-	-	openFDA substances
110.0822	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=41306.7	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=10326.7	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=101	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=350	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1010	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 10 of 10 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Hex-1-ene	209-753-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1548726

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1-Hexene?

1-Hexene has 10 NOAEL studies in the database. The lowest reported value is B38ZZ8C206 UNII. Source: openFDA substances.

What regulatory lists include 1-Hexene?

1-Hexene appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.

What are the occupational exposure limits for 1-Hexene?

Occupational exposure limits for 1-Hexene are set by ACGIH, CAL/OSHA, AIHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1-Hexene used in cosmetics?

Yes, 1-Hexene is also indexed as a cosmetic ingredient under the name Hexene (1-Hexene). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Hexene come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Hexene have different safety status in cosmetics vs industrial chemicals?

1-Hexene is classified GHS Danger (H225, H304, H319, H335, H336, H401) in the chemicals database but is restricted in EU cosmetics.

Is 1-Hexene used outside industrial chemicals?

1-Hexene also appears in cosmetics, pharmaceutical databases.