Is Diallyl Sulphide safe in cosmetics?
Diallyl Sulphide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Diallyl Sulphide
Also known as: 4-01-00-02097, BRN 1736016, EINECS 209-775-1, FEMA No. 2042, 2-Propenyl sulphide (+9 more)
INCI: DIALLYL SULFIDE
Diallyl Sulphide (CAS 592-88-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient, flavoring agent. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 592-88-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient, flavoring agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-prop-2-enylsulfanylprop-1-ene
InChIKey
UBJVUCKUDDKUJF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — GRAS (FEMA); FDA 21 CFR 172.515
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diallyl Sulphide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Diallyl Sulphide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 71 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 114 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diallyl Sulphide across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 337.5 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
458
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALLYL SULFIDE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
THIOALLYL ETHER | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Diallyl Sulphide.
Regulatory Flags
potential-allergen
fragrance-component
natural-origin
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diallyl Sulphide by CAS number or substance name.
Studies
5
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
COSMOS_DB
Known Synonyms
4-01-00-02097
BRN 1736016
EINECS 209-775-1
FEMA No. 2042
2-Propenyl sulphide
3,3-Thiobis(1-propene)
UNII-60G7CF7CWZ
3,3'-Thiobis-1-propene, 9CI
3-(Allylsulfanyl)-1-propene
4-Thia-1,6-heptadiene
Allyl sulphide
Dially monosulfide
Diallylsulfide
FEMA 2042
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIALLYL SULFIDE
ChEMBL ID
CHEMBL170458
Frequently Asked Questions
Is Diallyl Sulphide allowed in the EU?
Diallyl Sulphide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diallyl Sulphide do in cosmetics?
Diallyl Sulphide functions as: Fragrance ingredient, flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 592-88-1.
What is the NOAEL for Diallyl Sulphide?
The NOAEL (No Observed Adverse Effect Level) for Diallyl Sulphide is 50 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is Diallyl Sulphide used outside cosmetics?
Diallyl Sulphide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diallyl Sulphide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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