Is Dimethylaminopropylamine (DMAPA) safe in cosmetics?
Dimethylaminopropylamine (DMAPA) has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Dimethylaminopropylamine (DMAPA)
Also known as: 1,3-Propanediamine, N,N-dimethyl-, 1-Amino-3-dimethylaminopropane, BRN 0605293, gamma-(Dimethylamino)propylamine, N-Dimethyltrimethylenediamine (+3 more)
INCI: DIMETHYLAMINOPROPYLAMINE
Dimethylaminopropylamine (DMAPA) (CAS 109-55-7) is a cosmetic cosmetic ingredient functioning as Buffering agent / intermediate (primarily encountered as an impurity in CAPB. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 109-55-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethylaminopropylamine (DMAPA) is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H314, H317, H318, H335, H311).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering agent / intermediate (primarily encountered as an impurity in CAPB and amidoamine surfactants)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
N',N'-dimethylpropane-1,3-diamine
InChIKey
IUNMPGNGSSIWFP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted with CIR caveats — CIR QRA indicates no sensitisation concern at ≤ 0.01% DMAPA in raw CAPB
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethylaminopropylamine (DMAPA).
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
Sensitization Profile
Contact sensitization data for Dimethylaminopropylamine (DMAPA) based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
surfactant
EU Allergen Listed
no
Patch Test Positive Rate
2.0%
Cross-reactivity Group
amidoamine-group
Reaction Type
contact-dermatitis
Source: NACDG; IVDK; ESSCA
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosive
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1
Hazard Statements
- H226 Flammable liquid and vapour
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
9.1%
DPRA Lys %
-1%
KeratinoSens IC50
1337.92 µM
hCLAT CV75
276.7 µg/mL
LLNA EC3
3.5%
NESIL
875 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Source: LLNA: Gerberick et al. (2005) | Wright et al. (2001); DPRA: Nukada et al. 2013 [DOI:10.1016/j.tiv.2012.11.006] | Natsch et al. 2013 [DOI:10.1002/jat.2868]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868]; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Suspected
Evidence: Limited
(2024)
Health effects: Yes
Affected pathways: Estrogenic
Regulatory framework: REACH
Source list: II
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "surfactant", "cross_reactivity_group": "amidoamine-group", "patch_test_frequency_pct": "2.0", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "NACDG; IVDK; ESSCA"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1227
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hardener
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dimethylaminopropylamine (DMAPA).
Known Synonyms
1,3-Propanediamine, N,N-dimethyl-
1-Amino-3-dimethylaminopropane
BRN 0605293
gamma-(Dimethylamino)propylamine
N-Dimethyltrimethylenediamine
EINECS 203-680-9
Propylamine, 3-(N,N-dimethylamino)-
UNII-I98I2UEC03
Chemical Function
Hardener
No specific technical function
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1232234
Frequently Asked Questions
Is Dimethylaminopropylamine (DMAPA) allowed in the EU?
Dimethylaminopropylamine (DMAPA) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethylaminopropylamine (DMAPA) do in cosmetics?
Dimethylaminopropylamine (DMAPA) functions as: Buffering agent / intermediate (primarily encountered as an impurity in CAPB and amidoamine surfactants). It is classified as a cosmetic ingredient in our database. CAS number: 109-55-7.
Is Dimethylaminopropylamine (DMAPA) used outside cosmetics?
Dimethylaminopropylamine (DMAPA) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethylaminopropylamine (DMAPA) have different safety status in cosmetics vs industrial chemicals?
Dimethylaminopropylamine (DMAPA) is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H312, H314, H317, H318, H335, H311).
Compliance Tools
Check Dimethylaminopropylamine (DMAPA) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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