Is Butyl Butyrate safe in cosmetics?
Butyl Butyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Butyl Butyrate
Also known as: Butanoic acid, butyl ester, n-Butyl butyrate, Butyric acid, butyl ester, 4-02-00-00789, BRN 1747101 (+11 more)
INCI: BUTYL BUTYRATE
Butyl Butyrate (CAS 109-21-7) is a cosmetic cosmetic ingredient functioning as Solvent, masking agent, fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 109-21-7 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent, masking agent, fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
butyl butanoate
InChIKey
XUPYJHCZDLZNFP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate — supported by food-grade safety data and CIR group review
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Butyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Flammable
Hazard Class and Category
Flam. Liq. 3
Hazard Statements
- H226 Flammable liquid and vapour
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYL BUTYRATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Butyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Butanoic acid, butyl ester
n-Butyl butyrate
Butyric acid, butyl ester
4-02-00-00789
BRN 1747101
EINECS 203-656-8
FEMA No. 2186
UNII-1BHV00T1M4
Butyl N-butyrate
Butyl ester of butanoic acid
FEMA 2186
N-Butyl N-butanoate
N-Butyl N-butyrate
N-Butyl-N-butyrate
N-Butyric acid N-butyl ester
n-butyric n-butyl ester
Chemical Function
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Butyl Butyrate allowed in the EU?
Butyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Butyrate do in cosmetics?
Butyl Butyrate functions as: Solvent, masking agent, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 109-21-7.
Compliance Tools
Check Butyl Butyrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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