Also known as: 1,3-Propanediamine, N,N-dimethyl-, 1-Amino-3-dimethylaminopropane, BRN 0605293, gamma-(Dimethylamino)propylamine, N-Dimethyltrimethylenediamine (+3 more)
CAS 109-55-7
3-(Dimethylamino)propylamine (CAS 109-55-7) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H302; H314; H317. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for Dimethylaminopropylamine (DMAPA) →
3-(Dimethylamino)propylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H314, H317).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1 | H226; H302; H314; H317 | GHS02; GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 165.8 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 82.1 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 103.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >715.267 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 276.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =1.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 10.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -2 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 4 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 5.1 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 85.76 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 2.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 472.4 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| I98I2UEC03 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I98I2UEC03 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I98I2UEC03 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I98I2UEC03 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1337.92 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 30.2 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =1870 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 25 of 25 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-aminopropyldimethylamine | 203-680-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
3-(Dimethylamino)propylamine (CAS 109-55-7) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1 with signal word Danger. Hazard statements: H226; H302; H314; H317. Source: EU CLP Annex VI (ECHA).
3-(Dimethylamino)propylamine has 25 NOAEL studies in the database. The lowest reported value is -2 % via Dermal. Source: NTP_ICE_skin_sensitization.
3-(Dimethylamino)propylamine appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Yes, 3-(Dimethylamino)propylamine is also indexed as a cosmetic ingredient under the name Dimethylaminopropylamine (DMAPA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
3-(Dimethylamino)propylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H314, H317).
3-(Dimethylamino)propylamine also appears in cosmetics, pharmaceutical databases.