Is Butyl Isovalerate safe in cosmetics?
Butyl Isovalerate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Butyl Isovalerate
Also known as: 3-02-00-00698, BRN 1752803, Butyl isopentanoate, n-Butyl isopentanoate, n-Butyl isovalerate (+10 more)
INCI: BUTYL ISOVALERATE
Butyl Isovalerate (CAS 109-19-3) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 109-19-3 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
butyl 3-methylbutanoate
InChIKey
AYWJSCLAAPJZEF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Favorable — JECFA evaluation and FEMA GRAS status support adequate safety margins at fragrance-level use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Isovalerate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Skin irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
198
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYL ISOVALERATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/267
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Isovalerate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
3-02-00-00698
BRN 1752803
Butyl isopentanoate
n-Butyl isopentanoate
n-Butyl isovalerate
1-Butyl isovalerate
Butyl isovalerianate
n-Butyl 3-methylbutanoate
Butyl 3-methylbutyrate
EINECS 203-654-7
FEMA No. 2218
NSC 6187
UNII-4UX6V9QM2J
Butanoic acid, 3-methyl-, butyl ester
FEMA 2218
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Butyl Isovalerate allowed in the EU?
Butyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Isovalerate do in cosmetics?
Butyl Isovalerate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 109-19-3.
Is Butyl Isovalerate used outside cosmetics?
Butyl Isovalerate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Butyl Isovalerate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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