Is Cyclohexanol safe in cosmetics?
Cyclohexanol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Cyclohexanol
Also known as: 4-06-00-00020, BRN 0906744, Cyclohexanone cyclohexanol mixture, EINECS 203-630-6, Hydralin (+4 more)
INCI: CYCLOHEXANOL
Cyclohexanol (CAS 108-93-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient and possible solvent; assessed as a fragrance material by. NOAEL 143 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-93-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Cyclohexanol is classified GHS Danger (H302, H312, H315, H319, H332, H335, H412, H303) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient and possible solvent; assessed as a fragrance material by the Research Institute for Fragrance Materials (RIFM).
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
cyclohexanol
InChIKey
HPXRVTGHNJAIIH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Evaluated by RIFM; no specific FDA cosmetic restriction; use levels are self-regulated via IFRA Standards and internal safety assessments.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclohexanol.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cyclohexanol across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2
Hazard Statements
- H332 Harmful if inhaled
- H302 Harmful if swallowed
- H335 May cause respiratory irritation
- H315 Causes skin irritation
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
0243
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Severe eye irritant. | Irritation to the eyes, nose and throat of human subjects results at 100 ppm.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Cyclohexanol.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cyclohexanol by CAS number or substance name.
Studies
15
Lowest NOAEL
143 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-06-00-00020
BRN 0906744
Cyclohexanone cyclohexanol mixture
EINECS 203-630-6
Hydralin
Cicloesanolo
Cykloheksanol
UNII-8E7S519M3P
Hydrophenol
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
artificial_sweat; emissions; Europe; nondetect; Toys and children's products
artificial_saliva; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
Indirect additives food contact (10/2018)
IFRA Transparency
Europe
Canada; pharmaceutical
detected; Other indirect contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CYCLOHEXANOL
ChEMBL ID
CHEMBL32010
Frequently Asked Questions
Is Cyclohexanol allowed in the EU?
Cyclohexanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclohexanol do in cosmetics?
Cyclohexanol functions as: Fragrance ingredient and possible solvent; assessed as a fragrance material by the Research Institute for Fragrance Materials (RIFM).. It is classified as a cosmetic ingredient in our database. CAS number: 108-93-0.
Is Cyclohexanol used outside cosmetics?
Cyclohexanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cyclohexanol have different safety status in cosmetics vs industrial chemicals?
Cyclohexanol is classified GHS Danger (H302, H312, H315, H319, H332, H335, H412, H303) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Cyclohexanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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