NOAEL Studies Cosmetic Ingredient

Cyclohexanol NOAEL Studies

INCI: CYCLOHEXANOL

CAS: 108-93-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing ABmale listing type - - 1998-11-06 California Proposition 65 listing {"cancer_reproductive":"male","listed_date":"1998-11-06","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABmale listing type - - 1998-11-06 California Proposition 65 listing {"cancer_reproductive":"male","listed_date":"1998-11-06","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABmale listing type - - 1998-11-06 California Proposition 65 listing {"cancer_reproductive":"male","listed_date":"1998-11-06","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 27 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 910 mg/kg bw/day other: oral: drinking water - chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=43c80541-b882-4f68-9121-7ca0191c7443_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=43c80541-b882-4f68-9121-7ca0191c7443/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=60515f09-0816-4a81-8a69-7c3c9ddd84d1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 15 mg/kg bw/day rat subcutaneous - short-term repeated dose toxicity: other route dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=eac851f7-5cc2-418d-87c3-5ca99df467fa_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=eac851f7-5cc2-418d-87c3-5ca99df467fa/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=26f8f43e-2d87-4477-ac0e-b1ddb0c1f6a1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 455 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=77298e47-659d-443c-b7b5-0233d5ab7f09_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=77298e47-659d-443c-b7b5-0233d5ab7f09/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=clinical biochemistry; key_result=false; entry_uuid=dea2674c-1da9-4a22-87ba-0f907e590ab2
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 25 mg/kg bw/day rabbit oral: unspecified - short-term repeated dose toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=1bcef9a3-cb49-4d04-a140-e857d135c540_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=1bcef9a3-cb49-4d04-a140-e857d135c540/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1980; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=e63fda8e-e6b7-4560-b70b-c2aae0b3ae14
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 910 mg/kg bw/day other: oral: drinking water - chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=43c80541-b882-4f68-9121-7ca0191c7443_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=43c80541-b882-4f68-9121-7ca0191c7443/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=60515f09-0816-4a81-8a69-7c3c9ddd84d1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 15 mg/kg bw/day rat subcutaneous - short-term repeated dose toxicity: other route dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=eac851f7-5cc2-418d-87c3-5ca99df467fa_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=eac851f7-5cc2-418d-87c3-5ca99df467fa/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=26f8f43e-2d87-4477-ac0e-b1ddb0c1f6a1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 455 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=77298e47-659d-443c-b7b5-0233d5ab7f09_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=77298e47-659d-443c-b7b5-0233d5ab7f09/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=clinical biochemistry; key_result=false; entry_uuid=dea2674c-1da9-4a22-87ba-0f907e590ab2
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 25 mg/kg bw/day rabbit oral: unspecified - short-term repeated dose toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=1bcef9a3-cb49-4d04-a140-e857d135c540_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=1bcef9a3-cb49-4d04-a140-e857d135c540/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1980; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=e63fda8e-e6b7-4560-b70b-c2aae0b3ae14
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 910 mg/kg bw/day other: oral: drinking water - chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=43c80541-b882-4f68-9121-7ca0191c7443_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=43c80541-b882-4f68-9121-7ca0191c7443/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=60515f09-0816-4a81-8a69-7c3c9ddd84d1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 15 mg/kg bw/day rat subcutaneous - short-term repeated dose toxicity: other route dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=eac851f7-5cc2-418d-87c3-5ca99df467fa_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=eac851f7-5cc2-418d-87c3-5ca99df467fa/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=26f8f43e-2d87-4477-ac0e-b1ddb0c1f6a1
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 455 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=77298e47-659d-443c-b7b5-0233d5ab7f09_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=77298e47-659d-443c-b7b5-0233d5ab7f09/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=clinical biochemistry; key_result=false; entry_uuid=dea2674c-1da9-4a22-87ba-0f907e590ab2
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 25 mg/kg bw/day rabbit oral: unspecified - short-term repeated dose toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=1bcef9a3-cb49-4d04-a140-e857d135c540_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=1bcef9a3-cb49-4d04-a140-e857d135c540/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1980; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=e63fda8e-e6b7-4560-b70b-c2aae0b3ae14
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 143 mg/kg bw/day rat oral: drinking water - sub-chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=2da302c9-f2aa-40a8-aca7-25a43b3df8c6_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=2da302c9-f2aa-40a8-aca7-25a43b3df8c6/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-14; basis=other:; key_result=true; entry_uuid=27fc4197-d4c9-4153-a68b-e7dc338bb017
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=fa625e2b-c729-422c-a88c-89a5f7c8c18a_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=fa625e2b-c729-422c-a88c-89a5f7c8c18a/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=body weight and weight gain; key_result=true; entry_uuid=364d9468-00cb-47bc-9a51-7f93a3f1f128
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=fa625e2b-c729-422c-a88c-89a5f7c8c18a_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=fa625e2b-c729-422c-a88c-89a5f7c8c18a/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=changes in sex ratio; key_result=true; entry_uuid=9a96ab21-b095-4b5c-a3d5-adde3ee0f8c0
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 200 mg/kg bw/day rat intraperitoneal - short-term repeated dose toxicity: other route dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=871afd40-d690-4b75-b56a-988b7050c470_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=871afd40-d690-4b75-b56a-988b7050c470/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1981; basis=neuropathology; key_result=false; entry_uuid=0b1f0a35-f019-49c7-9dee-180c3b0a8312
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 462 mg/kg bw/day other: oral: drinking water - chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=43c80541-b882-4f68-9121-7ca0191c7443_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=43c80541-b882-4f68-9121-7ca0191c7443/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=b118515d-6083-4652-b61b-def7564979ad
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 143 mg/kg bw/day rat oral: drinking water - sub-chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=2da302c9-f2aa-40a8-aca7-25a43b3df8c6_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=2da302c9-f2aa-40a8-aca7-25a43b3df8c6/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-14; basis=other:; key_result=true; entry_uuid=27fc4197-d4c9-4153-a68b-e7dc338bb017
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=fa625e2b-c729-422c-a88c-89a5f7c8c18a_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=fa625e2b-c729-422c-a88c-89a5f7c8c18a/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=body weight and weight gain; key_result=true; entry_uuid=364d9468-00cb-47bc-9a51-7f93a3f1f128
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=fa625e2b-c729-422c-a88c-89a5f7c8c18a_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=fa625e2b-c729-422c-a88c-89a5f7c8c18a/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=changes in sex ratio; key_result=true; entry_uuid=9a96ab21-b095-4b5c-a3d5-adde3ee0f8c0
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 200 mg/kg bw/day rat intraperitoneal - short-term repeated dose toxicity: other route dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=871afd40-d690-4b75-b56a-988b7050c470_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=871afd40-d690-4b75-b56a-988b7050c470/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1981; basis=neuropathology; key_result=false; entry_uuid=0b1f0a35-f019-49c7-9dee-180c3b0a8312
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 462 mg/kg bw/day other: oral: drinking water - chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=43c80541-b882-4f68-9121-7ca0191c7443_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=43c80541-b882-4f68-9121-7ca0191c7443/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=b118515d-6083-4652-b61b-def7564979ad
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 143 mg/kg bw/day rat oral: drinking water - sub-chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=2da302c9-f2aa-40a8-aca7-25a43b3df8c6_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=2da302c9-f2aa-40a8-aca7-25a43b3df8c6/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-14; basis=other:; key_result=true; entry_uuid=27fc4197-d4c9-4153-a68b-e7dc338bb017
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=fa625e2b-c729-422c-a88c-89a5f7c8c18a_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=fa625e2b-c729-422c-a88c-89a5f7c8c18a/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=body weight and weight gain; key_result=true; entry_uuid=364d9468-00cb-47bc-9a51-7f93a3f1f128
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=fa625e2b-c729-422c-a88c-89a5f7c8c18a_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=fa625e2b-c729-422c-a88c-89a5f7c8c18a/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=changes in sex ratio; key_result=true; entry_uuid=9a96ab21-b095-4b5c-a3d5-adde3ee0f8c0
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 200 mg/kg bw/day rat intraperitoneal - short-term repeated dose toxicity: other route dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=871afd40-d690-4b75-b56a-988b7050c470_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=871afd40-d690-4b75-b56a-988b7050c470/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1981; basis=neuropathology; key_result=false; entry_uuid=0b1f0a35-f019-49c7-9dee-180c3b0a8312
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 462 mg/kg bw/day other: oral: drinking water - chronic toxicity: oral dossier=40e4d383-5bb9-4a72-ba75-040003642b8d.i6z; document=43c80541-b882-4f68-9121-7ca0191c7443_40e4d383-5bb9-4a72-ba75-040003642b8d.i6d; document_key=43c80541-b882-4f68-9121-7ca0191c7443/40e4d383-5bb9-4a72-ba75-040003642b8d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=b118515d-6083-4652-b61b-def7564979ad
NTP_ICE_acute_inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >3.6 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2348; Record_ID=acute_inhalation_678; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=3.6; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15181/7/3/3/?documentUUID=ca456449-218b-4ab8-96f2-10ae00be6dc3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_acute_inhalation LC50 >3.63 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2349; Record_ID=acute_inhalation_1610; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=3.63; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2060 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_799; row=7065; data_type=In Vivo; mixture=Chemical; chemical_name=Cyclohexanol; preferred_name=Cyclohexanol; dtxsid=DTXSID4021894; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4021894; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1550 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_798; row=7066; data_type=In Vivo; mixture=Chemical; chemical_name=Cyclohexanol; preferred_name=Cyclohexanol; dtxsid=DTXSID4021894; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4021894; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_797; row=7067; data_type=In Vivo; mixture=Chemical; chemical_name=Cyclohexanol; preferred_name=Cyclohexanol; dtxsid=DTXSID4021894; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4021894; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7158; RecordID=ARPathway2016_521; DatasetName=ARPathway2016; DTXSID=DTXSID4021894; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_eye_irritation 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation Draize rabbit irritation score 79.8 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=1215; Record_ID=eye_irritation_168; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=79.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_eye_irritation GHS Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=1211; Record_ID=eye_irritation_168; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_eye_irritation Intensity 0.31 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1217; Record_ID=eye_irritation_1302; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Vitrigel; Endpoint=Intensity; Response=0.31; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_eye_irritation Lag time 0 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1216; Record_ID=eye_irritation_1302; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_eye_irritation Plateau level 56 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1218; Record_ID=eye_irritation_1302; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Vitrigel; Endpoint=Plateau level; Response=56; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3359; Record_ID=skin_sensitization_invivo_850; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90217-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3358; Record_ID=skin_sensitization_invivo_850; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90217-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3363; Record_ID=skin_sensitization_invivo_850; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4021894; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90217-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021894; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021894
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =400 mg/kg bw/day Rat injection short-term; 10 days short-term LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Physiology: Osmolality; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604218_15604219:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d2f04270bea484968f58e9ecea4205c2
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =40.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630872:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_80eecaa31ff078911ca4dc78099bb9cc
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =614.488 mg/m3 Rat inhalation subchronic; 13 weeks reproduction developmental LONG_REF=Newton, P.E. (MPI Research, Inc.). An Inhalation Combined Repeat Dose Toxicity Study and Reproduction/Developmental Toxicity Screening Study (OECD 422) in Rats with Cyclohexanol, Report No. 683-004.2005.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: March 21, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=60816; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639104:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8aadd41be522e5d0bd11fda09a347200
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8E7S519M3P UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8E7S519M3P"}
openFDA substances FDA UNII substance identifier 8E7S519M3P UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8E7S519M3P"}
openFDA substances FDA UNII substance identifier 8E7S519M3P UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8E7S519M3P"}
openFDA substances FDA UNII substance identifier 8E7S519M3P UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8E7S519M3P"}