Is Chlorofluorocarbons (CFCs) safe in cosmetics?
Chlorofluorocarbons (CFCs) has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database.
Chlorofluorocarbons (CFCs)
Also known as: Methane, dichlorodifluoro-, CFC-12, Caswell No. 304, EINECS 200-893-9, EPA Pesticide Chemical Code 000014 (+9 more)
INCI: CHLOROFLUOROCARBONS
Chlorofluorocarbons (CFCs) (CAS 75-71-8) is a cosmetic cosmetic ingredient functioning as aerosol propellants. NOAEL 560 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 75-71-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Chlorofluorocarbons (CFCs) is prohibited in EU cosmetics but has active industrial GHS classifications (H280).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
aerosol propellants
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
CFCs are prohibited in cosmetics under the Clean Air Act due to ozone depletion potential
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chlorofluorocarbons (CFCs).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Chlorofluorocarbons (CFCs). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 75 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 82 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system and central nervous system. This may result in cardiac disorders and central nervous system depression. Exposure could cause lowering of consciousness. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Chlorofluorocarbons (CFCs) across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Heat transferring agent
Refrigerants
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Chlorofluorocarbons (CFCs).
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Chlorofluorocarbons (CFCs) by CAS number or substance name.
Studies
2
Lowest NOAEL
75 mg/kg bw/day
Highest NOAEL
82 mg/kg bw/day
COSMOS_DB
Known Synonyms
Methane, dichlorodifluoro-
CFC-12
Caswell No. 304
EINECS 200-893-9
EPA Pesticide Chemical Code 000014
Fluorocarbon-12
Kaiser chemicals 12
Propellant 12
RCRA waste number U075
Refrigerant 12
Ucon 12/halocarbon 12
Diclorodifluometano
Dwuchlorodwufluorometan
UNII-OFM06SG1KO
Chemical Function
Refrigerants
Heat transferring agent
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DICHLORODIFLUOROMETHANE
ChEMBL ID
CHEMBL2106634
Max Phase
-1
Frequently Asked Questions
Is Chlorofluorocarbons (CFCs) allowed in the EU?
Chlorofluorocarbons (CFCs) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Chlorofluorocarbons (CFCs) do in cosmetics?
Chlorofluorocarbons (CFCs) functions as: aerosol propellants. It is classified as a cosmetic ingredient in our database. CAS number: 75-71-8.
What is the NOAEL for Chlorofluorocarbons (CFCs)?
The NOAEL (No Observed Adverse Effect Level) for Chlorofluorocarbons (CFCs) is 75 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Chlorofluorocarbons (CFCs) used outside cosmetics?
Chlorofluorocarbons (CFCs) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Chlorofluorocarbons (CFCs) have different safety status in cosmetics vs industrial chemicals?
Chlorofluorocarbons (CFCs) is prohibited in EU cosmetics but has active industrial GHS classifications (H280).
Compliance Tools
Check Chlorofluorocarbons (CFCs) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
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Chemical family
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Is Chlorofluorocarbons (CFCs) in Your Products?
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