NOAEL Studies
Cosmetic Ingredient
Chlorofluorocarbons (CFCs) NOAEL Studies
INCI: CHLOROFLUOROCARBONS
CAS: 75-71-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 75 | mg/kg bw/day | dog | oral | 730 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 150 | mg/kg bw/day | rat | oral | 730 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 170 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 379 | mg/kg bw/day | rat | oral | 126 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 82 | mg/kg bw/day | dog | oral | 126 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOAEL | =15 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=f250db9cf846d959; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.5e1 mg/kg-day; system=Other; basis=Reduced body weight; point_of_departure=NOAEL : 1.5e1 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID6020436; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=40; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0040_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.2 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=016a865a8107d012; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2e-1; system=Other; basis=Reduced body weight; point_of_departure=NOAEL : 1.5e1 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID6020436; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=40; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0040_summary.pdf |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >1000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10035; row=9937; data_type=In Vivo; mixture=Chemical; chemical_name=Dichlorodifluoromethane; preferred_name=Dichlorodifluoromethane; dtxsid=DTXSID6020436; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020436; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 1.369 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=2313; Record_ID=adme_parameters_1222; Data_Type=Measured; DTXSID=DTXSID6020436; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.369; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020436 |
| NTP_ICE_adme_parameters | Clint | 0.2524 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2314; Record_ID=adme_parameters_1222; Data_Type=Measured; DTXSID=DTXSID6020436; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.2524; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020436 |
| NTP_ICE_adme_parameters | Fu | 0.411 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=2311; Record_ID=adme_parameters_1222; Data_Type=Measured; DTXSID=DTXSID6020436; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.411; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020436 |
| NTP_ICE_adme_parameters | Fu | 0.773 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2312; Record_ID=adme_parameters_1222; Data_Type=Measured; DTXSID=DTXSID6020436; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.773; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020436 |
ToxValDB_Alaska_DEC 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Alaska_DEC | RfC | =0.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446130:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=7f462246af4fd30a3ecafba5cec4bef6 |
| ToxValDB_Alaska_DEC | RfC | =0.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446130:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=7f462246af4fd30a3ecafba5cec4bef6 |
| ToxValDB_Alaska_DEC | RfD | =0.046 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446127:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=dc243a65e2873db2a08e9f233ea8dcd3 |
| ToxValDB_Alaska_DEC | RfD | =0.0571 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446128:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=eadf50575161c14a65f5b05b6b5ba4aa |
| ToxValDB_Alaska_DEC | RfD | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446129:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=75bb845892f88d34458ff2f58fb35609 |
| ToxValDB_Alaska_DEC | RfD | =0.046 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446127:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=dc243a65e2873db2a08e9f233ea8dcd3 |
| ToxValDB_Alaska_DEC | RfD | =0.0571 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446128:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=eadf50575161c14a65f5b05b6b5ba4aa |
| ToxValDB_Alaska_DEC | RfD | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446129:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=75bb845892f88d34458ff2f58fb35609 |
ToxValDB_ECHA_IUCLID 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEC | ~150 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b44ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/8?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15817409:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_001315b56c35af647ff4bb1cc78d1934 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=989044 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d216e4b0a7c65d231881; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/9/3?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15820660:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37152afcd0ef62e1f523e30f712c15c0 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=24726.1 | mg/m3 | Dog | inhalation | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/6/3?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15827297:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f209304c60be096a633d9095ccc21cba |
| ToxValDB_ECHA_IUCLID | NOAEC | >=49452.2 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/6/3?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15829152:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_241c893e594c0ff5d246928099a96e5f |
| ToxValDB_ECHA_IUCLID | NOAEL | >179 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bee19; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/9/3?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15820891:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1c6a497f2c15c25e185833af868ddb3b |
| ToxValDB_ECHA_IUCLID | NOAEL | >170 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bee1b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/9/3?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15821496:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fc646ae4ef37d8cbabbe98aa89936885 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=171 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bee1b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/9/3?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: food consumption and compound intake|maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=ECHA IUCLID:15822810:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a6347a50bca633a68c74e5bbc201aef8 |
| ToxValDB_ECHA_IUCLID | NOEC | >=24726.1 | mg/m3 | Mouse | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c836e4b0a7c65d217603; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/8?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15819367:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d5f020cf0b1308ca8d7d100a63314bb |
| ToxValDB_ECHA_IUCLID | NOEC | >=989044 | mg/m3 | Rabbit | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d216e4b0a7c65d23188b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/9/3?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820873_15821817:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f299a9b48fb7ecf621be5255e30549e7 |
| ToxValDB_ECHA_IUCLID | NOEL | >150 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9d38; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12142/7/9/2?documentUUID=ce2c5694-f001-482e-85cf-d892c4eb9785; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15857076:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5a68976ff34ecfc85b3c10c549a17e9a |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1657 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631092:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fba8516512314690ea57ef6bde10eb58 |
ToxValDB_IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | NOAEL | =15 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=Sherman, H. 1974. Long-term feeding studies in rats and dogs with dichlorodifluoromethane (Freon 12 Food Freezant). Haskell Laboratory for Toxicology and Industrial Medicine Report No. 24-74.; TITLE=Long-term feeding studies in rats and dogs with dichlorodifluoromethane (Freon 12 Food Freezant); AUTHOR=Sherman, H; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4cf0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=40; TOXICOLOGICAL_EFFECT=reduced body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644446_15644448:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4c05ffbf45659ea25693cfe9d416ff77 |
ToxValDB_MN_MDH_HHBW 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_MN_MDH_HHBW | LOAEL | =150 | mg/kg bw/day | Rat | oral | - | repeat dose other | LONG_REF=EPA. Integrated Risk Information System. Dichlorodifluoromethane. (Last revised: 11/01/95) http://www.epa.gov/iris/subst/0040.htm (Accessed: 09/25/2002 & 3/14/07); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4e41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/gw/dichlorodiflu.pdf; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=reduced body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=MN MDH HHBW:15952788:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_190704d07e52fbeae30c77e0507a7525 |
ToxValDB_PPRTV_(CPHEA) 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | LOAEL (HEC) | =985 | mg/m3 | Guinea Pig | inhalation | subchronic; 6 weeks | subchronic | LONG_REF=Prendergast et al. 1967; AUTHOR=Prendergast et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1680; TOXICOLOGICAL_EFFECT=reduced body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=PPRTV (CPHEA):15653523:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c6fa723f913a3f9a0d2ba233785b18bc |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Prendergast et al. 1967; AUTHOR=Prendergast et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1680; TOXICOLOGICAL_EFFECT=Decreased body weight gain in guinea pigs; STUDY_GROUP=PPRTV (CPHEA):15653522:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8ff8d1164e4248121cfe2e475e12d7b6 |
| ToxValDB_PPRTV_(CPHEA) | RfD (provisional) | =0.05 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Sherman 1974; AUTHOR=Sherman; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1680; TOXICOLOGICAL_EFFECT=Decreased body weight gain in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653564:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_067953ffee6b09f04c99d8df6c764e74 |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =0.1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650015:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd1c0b15e6175b3eb29de49ac06d2063 |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=1.5 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afcdbe4b0d99f5a87d478; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/647; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=WHO JECFA ADI:15715447:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3baf319b94ec9ce51274acee883ea9a0 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | OFM06SG1KO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CCl2F2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OFM06SG1KO"} |
| openFDA substances | FDA UNII substance identifier | OFM06SG1KO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CCl2F2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OFM06SG1KO"} |
| openFDA substances | FDA UNII substance identifier | OFM06SG1KO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CCl2F2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OFM06SG1KO"} |
| openFDA substances | FDA UNII substance identifier | OFM06SG1KO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CCl2F2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OFM06SG1KO"} |