Also known as: 2-Naphthalenaminium, 8-(2-(4-aminophenyl)diazenyl)-7-hydroxy-N,N,N-trimethyl-, chloride (1:1), (8-((p-Aminophenyl)azo)-7-hydroxy-2-naphthyl)trimethylammonium chloride, 2-Naphthalenaminium, 8-((4-aminophenyl)azo)-7-hydroxy-N,N,N-trimethyl-, chloride, 2-Naphthalenaminium, 8-[2-(4-aminophenyl)diazenyl]-7-hydroxy-N,N,N-trimethyl-, chloride (1:1)
INCI: BASIC BROWN 16
Basic Brown 16 (CAS 26381-41-9) is a cosmetic cosmetic ingredient functioning as Hair colorant (direct, non-oxidative azo dye). NOAEL 33 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; 2 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 26381-41-9 →
Basic Brown 16 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Basic Brown 16.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Basic Brown 16. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg | dermal | rabbit | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =0.095 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.095 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.095 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.095 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =33 mg/kg bw/day | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =33 mg/kg bw/d | oral | - | irritation | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for Basic Brown 16 across SCCS product categories, with measured dermal absorption where available.
Contact sensitization data for Basic Brown 16 based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 2 | Non-oxidative hair dye (direct) |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.58 | method=measured | - | - |
| measured | 0.89 | method=measured | - | - |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Basic Brown 16.
Public NOAEL study rows linked to Basic Brown 16 by CAS number or substance name.
Units vary across source rows: mg/kg bw, mg/kg bw/day, mg/kg bw/d
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.58 | method=measured | - |
| 0.89 | method=measured | - |
Basic Brown 16 has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Basic Brown 16 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
Basic Brown 16 functions as: Hair colorant (direct, non-oxidative azo dye). It is classified as a cosmetic ingredient in our database. CAS number: 26381-41-9.
The NOAEL (No Observed Adverse Effect Level) for Basic Brown 16 is =50 mg/kg based on a repeated dose toxicity study via dermal route in rabbit. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Basic Brown 16 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Basic Brown 16 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H319).
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