What is the NOAEL for Basic Brown 16?
Basic Brown 16 has 100 NOAEL studies in the database. The lowest reported value is 0.095 mg/kg bw via oral in rat. Source: SCCS_vision_codex.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Basic Brown 16
Also known as: 2-Naphthalenaminium, 8-(2-(4-aminophenyl)diazenyl)-7-hydroxy-N,N,N-trimethyl-, chloride (1:1), (8-((p-Aminophenyl)azo)-7-hydroxy-2-naphthyl)trimethylammonium chloride, 2-Naphthalenaminium, 8-((4-aminophenyl)azo)-7-hydroxy-N,N,N-trimethyl-, chloride, 2-Naphthalenaminium, 8-[2-(4-aminophenyl)diazenyl]-7-hydroxy-N,N,N-trimethyl-, chloride (1:1)
CAS 26381-41-9
Basic Brown 16 (CAS 26381-41-9) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Basic Brown 16 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Basic Brown 16
CAS Number
26381-41-9
DTXSID
DTXSID20874043
Molecular Formula
C19H20N4O.ClH
InChI Key
UXEAWNJALIUYRH-UHFFFAOYSA-N
Monoisotopic Mass
356.140389
Synonyms
2-Naphthalenaminium, 8-(2-(4-aminophenyl)diazenyl)-7-hydroxy-N,N,N-trimethyl-, chloride (1:1)(8-((p-Aminophenyl)azo)-7-hydroxy-2-naphthyl)trimethylammonium chloride2-Naphthalenaminium, 8-((4-aminophenyl)azo)-7-hydroxy-N,N,N-trimethyl-, chloride2-Naphthalenaminium, 8-[2-(4-aminophenyl)diazenyl]-7-hydroxy-N,N,N-trimethyl-, chloride (1:1)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.5 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1.2 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1.66 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.1 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.1 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.1 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.1 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3.1 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 7 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 8 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 33 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =50 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 65.7 | % | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =89.1 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| >100 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 169 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6024 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| QEJ5GK0TG1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QEJ5GK0TG1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QEJ5GK0TG1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QEJ5GK0TG1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 150 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =0.095 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.095 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.095 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.095 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =0.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =0.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =0.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =1.2 | % | NOAEL | - | - | SCCS_vision_codex |
| =1.2 | % | NOAEL | - | - | SCCS_vision_codex |
| =1.2 | % | NOAEL | - | - | SCCS_vision_codex |
| =1.2 | % | NOAEL | - | - | SCCS_vision_codex |
| =1.66 | - | NOAEL | - | - | SCCS_vision_codex |
| =1.66 | - | NOAEL | - | - | SCCS_vision_codex |
| =1.66 | - | NOAEL | - | - | SCCS_vision_codex |
| =1.66 | - | NOAEL | - | - | SCCS_vision_codex |
| =3.1 | - | NOAEL | - | - | SCCS_vision_codex |
| =3.1 | - | NOAEL | - | - | SCCS_vision_codex |
| =3.1 | - | NOAEL | - | - | SCCS_vision_codex |
| =3.1 | - | NOAEL | - | - | SCCS_vision_codex |
| =7 | - | NOAEL | - | - | SCCS_vision_codex |
| =7 | - | NOAEL | - | - | SCCS_vision_codex |
| =7 | - | NOAEL | - | - | SCCS_vision_codex |
| =7 | - | NOAEL | - | - | SCCS_vision_codex |
| =8 | - | NOAEL | - | - | SCCS_vision_codex |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [8-[(p-aminophenyl)azo]-7-hydroxy-2-naphthyl]trimethylammonium chloride | 247-640-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1684/25 | 2 February 2026 | not safe | - | mutagenicity/genotoxicity (in vitro gene mutations, chromosomal aberrations) |
| SCCS/1486/12 | 11 December 2012 | insufficient data | - | mutagenic potential unresolved; impurity characterisation required |
| SCCP/1166/08 | 30 September 2008 | insufficient data | - | genotoxicity clarification needed; impurity concerns |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include Basic Brown 16?
Basic Brown 16 appears on 1 regulatory/inventory list including Europe; Personal care - hair coloring. Source: EPA CPDat.
Is Basic Brown 16 used in cosmetics?
Yes, Basic Brown 16 is also indexed as a cosmetic ingredient under the name Basic Brown 16. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Basic Brown 16 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Basic Brown 16 have different safety status in cosmetics vs industrial chemicals?
Basic Brown 16 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H319).
Is Basic Brown 16 used outside industrial chemicals?
Basic Brown 16 also appears in cosmetics databases.