Is 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine safe in cosmetics?
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine
INCI: 2-CHLORO-5-NITRO-N-HYDROXYETHYL P-PHENYLENEDIAMINE
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine (CAS 50610-28-1) is a cosmetic cosmetic ingredient functioning as Hair dyeing (semi-permanent/direct dye). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 50610-28-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (semi-permanent/direct dye)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-(4-amino-2-chloro-5-nitroanilino)ethanol
InChIKey
QNJWQAYYVNKOKR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No specific FDA prohibition; coal-tar hair dyes carry the statutory exemption with caution labeling under FD&C Act §601(a)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1318
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1318
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine.
Regulatory Flags
potential-allergen
eu_banned_cosmetics
eu_cosing_listed
Chemical Function
Dye
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
banned; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine allowed in the EU?
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine do in cosmetics?
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine functions as: Hair dyeing (semi-permanent/direct dye). It is classified as a cosmetic ingredient in our database. CAS number: 50610-28-1.
Is 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine used outside cosmetics?
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine have different safety status in cosmetics vs industrial chemicals?
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
Compliance Tools
Check 2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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