Is Thymoquinone safe in cosmetics?
Thymoquinone has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Antioxidant
Thymoquinone
Also known as: BRN 1939047, 2,5-Cyclohexadiene-1,4-dione, 5-isopropyl-2-methyl-, p-Cymene-2,5-dione, EINECS 207-721-1, NSC 2228 (+1 more)
INCI: THYMOQUINONE
Thymoquinone (CAS 490-91-5) is a cosmetic antioxidant functioning as Antioxidant, Antimicrobial, Anti-Inflammatory, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 490-91-5 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Antimicrobial, Anti-Inflammatory, Skin Conditioning
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione
InChIKey
KEQHJBNSCLWCAE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Nigella sativa listed as GRAS for food use by FDA. Under MoCRA, subject to general product safety but no ingredient-level restriction.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thymoquinone.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Thymoquinone.
Regulatory Flags
ALLERGEN
Known Synonyms
BRN 1939047
2,5-Cyclohexadiene-1,4-dione, 5-isopropyl-2-methyl-
p-Cymene-2,5-dione
EINECS 207-721-1
NSC 2228
Thymoquinon
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
THYMOQUINONE
ChEMBL ID
CHEMBL1672002
Max Phase
2
Frequently Asked Questions
Is Thymoquinone allowed in the EU?
Thymoquinone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thymoquinone do in cosmetics?
Thymoquinone functions as: Antioxidant, Antimicrobial, Anti-Inflammatory, Skin Conditioning. It is classified as a Antioxidant in our database. CAS number: 490-91-5.
Is Thymoquinone used outside cosmetics?
Thymoquinone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Thymoquinone compliance across multiple jurisdictions:
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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