Is 2-Acetylhydroquinone safe in cosmetics?
2-Acetylhydroquinone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
2-Acetylhydroquinone
Also known as: Ethanone, 1-(2,5-dihydroxyphenyl)-, Acetophenone, 2′,5′-dihydroxy-, 1-(2,5-Dihydroxyphenyl)ethan-1-one, 1-Acetyl-2,5-dihydroxybenzene, 2,5-Dihydroxy-1-acetylbenzene (+12 more)
INCI: 2-ACETYLHYDROQUINONE
2-Acetylhydroquinone (CAS 490-78-8) is a cosmetic cosmetic ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 490-78-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(2,5-dihydroxyphenyl)ethanone
InChIKey
WLDWSGZHNBANIO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Acetylhydroquinone.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Bleaching agent
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for 2-Acetylhydroquinone.
Known Synonyms
Ethanone, 1-(2,5-dihydroxyphenyl)-
Acetophenone, 2′,5′-dihydroxy-
1-(2,5-Dihydroxyphenyl)ethan-1-one
1-Acetyl-2,5-dihydroxybenzene
2,5-Dihydroxy-1-acetylbenzene
2-Acetyl-1,4-benzenediol
2′,5′-Dihydroxyacetophenone
Quinacetophenone
4-08-00-01803
Acetylhydroquinone
BRN 0637903
2,5-Dihydroxyacetophenone
EINECS 207-716-4
NSC 3759
UNII-K1H7QH11ZH
EC No.: 207-716-4
207-716-4
Chemical Function
Antioxidant
Softener and conditioner
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2348532
Frequently Asked Questions
Is 2-Acetylhydroquinone allowed in the EU?
2-Acetylhydroquinone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Acetylhydroquinone do in cosmetics?
2-Acetylhydroquinone functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 490-78-8.
Is 2-Acetylhydroquinone used outside cosmetics?
2-Acetylhydroquinone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Acetylhydroquinone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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